Project Grant F32AI194439
- This $128,461 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to determine the role of antibody epitope specificity in regulating Fc effector functions against SARS-CoV-2 and other viral pathogens. The research aims to integrate deep mutational scanning into systems serology to map the epitope specificities within IgG subclass and FcγR binding...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to develop broadly inhibitory alphavirus antibody therapies. The $1,687,240 award, with a performance period from June 6, 2025 to May 31, 2030, will fund efforts to engineer Fc mutations into existing broadly protective antibodies and perform viral escape studies to define mechanisms of...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $899,935 to the Scripps Research Institute to identify novel B cell epitopes on the SARS-CoV-2 spike protein and other human coronaviruses. The key objectives are to: 1) Identify unexplored epitopes on the SARS-CoV-2 spike, 2) Uncover cryptic epitopes that have been understudied, and 3) Find pan-Sarbecovirus,...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $108,486 to the Scripps Research Institute to develop soluble and membrane-bound immunogens that can shepherd the maturation of broadly neutralizing antibodies (bnAbs) targeting the highly conserved membrane proximal external region (MPER) of the HIV-1 envelope protein. The goal is to advance the quest for a...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
- This $451,000.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, supports research to investigate the manipulation of antibody responses by a retrovirus. The research aims to enhance understanding of how pathogens can directly or indirectly modulate B cells, which play a critical role in providing long-term protective immunity. Specifically, the study will examine...
- This Project Grant award, valued at $416,276.00 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate factors that modulate the Fc-mediated immune responses of antibodies. The research seeks to increase the potency of protection resulting from antibodies requiring Fc functions for influenza virus or antibodies against Streptococcus pneumoniae. The University...
- This Project Grant award, valued at $102,444, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The goal of the project is to uncover structural insights into the N-terminal core of the SARS-CoV-2 nonstructural protein 1 (NSP1) and establish its specificity in regulating host gene expression, a process known as "host shutoff." This research aims to advance the...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $483,825 to Yale University to elucidate how broadly neutralizing antibodies (bNAbs) targeting the membrane-proximal external region (MPER) of the HIV-1 envelope glycoprotein (Env) engage with native virus particles and interfere with virus-host membrane fusion. The study will utilize cryo-electron tomography...
- This $122,597 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to analyze the function and antibody-mediated inhibition of the malaria vaccine candidate protein PF3D7_1136200. The project aims to characterize this promising but previously uncharacterized blood-stage malaria antigen, with the goal of advancing development of a highly efficacious malaria vaccine. The...
This Project Grant award of $156,080 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The award supports research to uncover the underlying biology and key properties that define "broadly neutralizing" antibodies - those that can recognize and neutralize a wide range of related pathogens. Using SARS-CoV-2 as a model, the research aims to determine whether the rarity of such broadly neutralizing antibodies contributes to their ability to evade viral escape, and whether some epitopes are more difficult for pathogens to evolve away from. The research will be conducted at the University of Arizona from January 2026 through September 2028, with the goal of providing a deeper understanding of the relationship between antibody epitopes and resistance to viral evolution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/10/25 | ||
| Not listed | $0 | 9/10/25 | ||
| Not listed | $0 | 9/10/25 | ||
| Not listed | $78.0k | 7/11/25 | ||
| Not listed | $78.0k | 7/11/25 |