Project Grant R21AI190814
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $254,478 Project Grant to The University of Texas Southwestern Medical Center under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective May 16, 2025, with completion targeted for April 30, 2027. The award supports research to identify and characterize resistance mechanisms to peptide-phosphorodiamidate morpholino oligomers (PPMOs), a novel antisense...
- Federal Grant Award Summary Texas A&M University System Health Science Center received a $624,267 Project Grant award dated August 11, 2025, from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant funds a five-year research initiative (through July 31, 2030) focused on developing methods to understand how small molecule compounds penetrate the cellular envelope of gram-negative bacteria, with...
- Federal Grant Award Summary Texas A&M Engineering Experiment Station received a $637,275 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded May 28, 2025, with completion targeted for April 30, 2030. This research initiative investigates rapid stress response mechanisms in gram-negative bacterial pathogens, specifically examining how existing porins in outer membranes contribute...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $109,476 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin-Madison on November 30, 2025, with completion scheduled for May 31, 2027. This research project focuses on understanding the molecular mechanisms underlying multidrug efflux transporter function in bacteria, specifically investigating how the NorA transporter exports...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $429,000 to the University of Texas at Dallas under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a two-year project spanning August 1, 2025 through July 31, 2027. This Project Grant supports research to develop innovative methods for measuring virus distribution in bioaerosols and understanding pathogen viability decay based on chemical composition. The research focuses...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Texas Medical Branch at Galveston a $440,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period of August 1, 2025, through July 31, 2027. This award funds investigator-initiated biomedical research focused on understanding rickettsial pathogenesis mechanisms and exosome-mediated disease transmission. The research project...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Texas Health Science Center at Houston $429,000.00 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a Project Grant beginning February 2, 2026, with completion targeted for January 31, 2028. The primary deliverable is the development and application of spatial transcriptional analysis technology to study host-pathogen interactions in fungal...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Texas Health Science Center at Houston $418,360 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on August 11, 2025, for a project extending through July 31, 2027. The award supports systematic analysis of Treponema pallidum gene expression under host infection-related conditions to address the recent resurgence of venereal and congenital syphilis in the...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $392,634 Project Grant effective May 13, 2025, through April 30, 2030, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds the development of a novel nanoimmunotherapeutic treatment approach targeting multidrug-resistant (MDR) bacterial infections, specifically gram-negative ESKAPE pathogens including...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Texas Medical Branch at Galveston a Project Grant totaling $520,128 under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2030. This five-year research project investigates molecular mechanisms by which Ehrlichia chaffeensis, a gram-negative bacterium causing human monocytotropic ehrlichiosis, manipulates host cell...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Texas at Dallas $434,625 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for a project grant initiated February 17, 2026, with completion targeted for January 31, 2028. This research project investigates the genetic mechanisms underlying minocycline antibiotic resistance in Acinetobacter baumannii, a WHO and CDC priority pathogen. The research employs machine learning analysis to identify resistance correlates in clinical isolates and examines the role of the RuvB DNA repair protein in conferring resistance phenotypes. Deliverables include experimental validation studies demonstrating that RuvB gene disruption increases antibiotic susceptibility thresholds and promotes enhanced biofilm formation and biomass production compared to wildtype strains. The project outputs advance scientific understanding of previously undocumented mechanisms of antibiotic resistance in a critical nosocomial pathogen, potentially informing development of therapeutic interventions to combat the international spread of minocycline-resistant strains. Research findings and associated data generated through this NIAID-funded initiative will contribute to the broader public health objective of addressing emerging antibiotic resistance threats and improving clinical treatment options for A. baumannii infections.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $434.6k | 2/17/26 |