This $910,860 project grant was awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Johns Hopkins University to conduct research on the mechanisms used by the bacterial pathogen Legionella to maintain the integrity of its replication vacuole within host cells. The goal is to characterize the cell-surface signaling system Legionella employs to sense and respond to defects in the replication vacuole, as this...
This $143,784 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by The Johns Hopkins University to characterize how the bacterium Legionella pneumophila, the causative agent of Legionnaires' disease, inhibits host cell translation.
The key objectives of the research are to: 1) determine the mechanism of action of the Legionella effector protein SidL, which inhibits host...
This $1,361,909 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to identify and characterize genes required for the cytosolic survival of the bacterial pathogen Listeria monocytogenes. The project aims to understand how this intracellular pathogen has adapted to thrive in the host cell cytosol, a challenging environment. Specifically, the research focuses on elucidating the roles of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $728,244 to the University of Utah to conduct research on the molecular mechanisms of type III secretion systems in Salmonella and other Gram-negative pathogens. The overarching goal is to develop a deeper understanding of how these bacterial "injectisome" structures selectively translocate virulence factors into host...
The National Institute of Allergy and Infectious Diseases, through the Allergy and Infectious Diseases Research (CFDA 93.855) program, awarded a $396,525 Project Grant to The Washington University to study the relationship between bacterial metal content and cellular metabolism at the single-cell level. The project, titled "Connecting the Bacterial Metallome to Cellular Metabolism at Single Cell Resolution," aims to develop methods to simultaneously measure metal concentrations and...
This $1,447,515 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to better understand how typhoidal Salmonella serovars, which cause enteric fever, interact with and manipulate macrophages to evade the immune system.
The research employs unbiased methodologies, including random barcode transposon-site sequencing, genomic comparisons, and transcriptional profiling, to identify...
This federal Project Grant award of $1,444,195.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to discover strategies for enhancing the activity of existing and new topoisomerase inhibitor antibiotics against persistent and resistant Escherichia coli and Pseudomonas aeruginosa bacterial infections. The research aims to identify metabolites that can modulate bacterial...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $531,245 to Yale University to conduct research on the structure and function of the Salmonella type III secretion sorting platform. This 5-year research project from January 2025 to December 2029 will use a multidisciplinary approach involving bacterial genetics, biochemistry, super-resolution microscopy, cryo-EM, and cryo-ET to...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $123,398 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Duke University to explore the role of the sigma factor SigE in Mycobacterium tuberculosis (MTB) granulomas. The research aims to uncover novel bacterial cell envelope components that impact both MTB survival and the host immune response within granulomas, using the zebrafish-Mycobacterium marinum model. Specifically,...
This $143,784 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to understand the link between glutamine starvation, immune pressure vulnerability, and reduced antibiotic tolerance in Mycobacterium tuberculosis (MTB). The award recipient, the University of Massachusetts Medical School, will conduct experiments using engineered MTB strains to assess how glutamine starvation impacts antibiotic...