The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,447,515 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Leland Stanford Junior University (Stanford University) to conduct research on how typhoidal Salmonella serovars interact with macrophages. The research aims to bridge the gap in understanding how these Salmonella strains, which cause devastating human infections, outmaneuver the immune system by thriving in macrophages - a critical aspect of their virulence. The research approaches include unbiased methodologies such as random barcode transposon-site sequencing, genomic comparisons across Salmonella serovars, and transcriptional profiling of macrophages infected by Salmonella Typhi. The findings are expected to uncover typhoidal-specific fitness traits and virulence factors that enable these pathogens to manipulate the host immune response, which can inform new strategies for combating this formidable infectious disease.
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