This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $479,249 to Washington University to conduct research on the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The research aims to understand how neutrophil A20 signaling contributes to organ damage in sepsis, utilizing biochemical, cell biological, and intravital imaging...
This Project Grant award of $1,024,897.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, supports research by the University of Pennsylvania to investigate the innate immune response to Yersinia bacterial infections. The key objectives are to: 1) define how monocyte-specific TNF receptor signaling contributes to IL-1 expression in immune cells, 2) dissect the role of intestinal epithelial IL-1...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program, provides $430,760 to the University of Pittsburgh to conduct research on improving host defense against the deadly Gram-negative bacterium, Pseudomonas aeruginosa. The key objectives are to: 1) Determine the role of the CXCR4 chemokine receptor and galectin-3 protein in the protective function of lung...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $684,206 to the University of Maryland, Baltimore to develop immunomodulatory nanoparticles (INPs) as a novel therapeutic approach to improve outcomes for patients with sepsis. The primary objectives are to: 1) evaluate the immunomodulatory properties of INPs to maximize therapeutic efficacy in a sepsis...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $784,217 to the Research Foundation of the City University of New York (RFCUNY) - Lehman College to conduct research characterizing how cellular death signaling pathways contribute to both protective and injurious inflammation during bacterial infections. The research aims to identify novel signaling mechanisms...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $707,534 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center. The grant supports research to investigate the mechanisms by which the ZFAND6 protein regulates mitophagy, inflammation, and the NLRP3 inflammasome. The research aims to provide new insights into the...
The University of Rochester was awarded a $462,000 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to investigate how the microbiome in healthy human blood differentially "primes" or trains neutrophils, leading to varied inflammatory responses during sepsis. The research aims to elucidate the mechanisms underlying this microbiome-mediated immune...
This federal Project Grant award, valued at $472,210.00 and effective June 23, 2025 through May 31, 2027, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research by the University of Massachusetts Medical School to investigate the spatiotemporal relationship between CD4+ T resident memory cells and neutrophil recruitment in the lungs during pneumonia in experienced...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $578,093 to the University of Massachusetts Medical School to conduct research on a novel human damage-associated molecular pattern (DAMP) receptor, its murine counterpart, and their ligand, GAPDH. The research aims to elucidate the structure, function, and pathophysiology of this DAMP receptor system in both humans...
This Project Grant award of $868,776.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to: Identify the direct regulatory targets of the RNA-binding protein PhaF under standard lab conditions, infection-relevant conditions, and in clinical isolates to...