The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $704,041 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of California at Riverside. The grant supports research to investigate sex-dependent innate immune mechanisms that regulate type 2 immunity and obesity. The research aims to study macrophage-eosinophil interactions and the role of the RELMA protein in protecting against diet-induced obesity and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $171,254 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Nimml Institute Inc., a 501(c)(3) non-profit research organization in Blacksburg, Virginia. The grant, effective from December 1, 2024 to November 30, 2026, aims to elucidate novel immunometabolic mechanisms that intercept bacterial toxin internalization and processing to suppress cell damage caused by Clostridioides difficile...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $479,730 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The 5-year grant, effective from December 1, 2024 to November 30, 2029, will support research to elucidate the mechanisms by which prophages (viral DNA) in the gut symbiont Limosilactobacilus reuteri modulate the production of the antimicrobial compound reuterin. The research aims to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $427,625 to the University of Wisconsin-Madison to develop an innovative approach for producing recombinant therapeutic proteins in probiotic bacteria. The goal is to create a dietary sugar-regulated system for expressing proteins like interleukin-22 in the gastrointestinal tract, without relying on antibiotic...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $226,641 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The grant, awarded on December 5, 2024 with a completion date of November 30, 2026, will support research to examine how the intestinal microbiome and the pattern recognition receptor NOD2 expressed in intestinal epithelial cells impact pathogenesis of Coxsackievirus B3, an enteric virus...
This federal Project Grant award of $451,292.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to uncover neuronal mechanisms that orchestrate metabolic adaptations to bacterial infections, with a focus on delineating the role of the brain-liver axis in modulating metabolic responses. The research seeks to identify neurocircuits in the hypothalamus that monitor circulating lipoproteins and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $267,310 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Illinois in Chicago. The grant, awarded on August 27, 2024, supports research to evaluate the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence. The project aims to determine how this lipoic acid transfer protein interfaces with other metabolic enzymes to control...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $661,693 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The University of Iowa. The grant, awarded on June 16, 2025, supports research to define the structure and function of a new family of peptidoglycan crosslinking enzymes found in Clostridioides difficile, an opportunistic pathogen and leading cause of hospital-acquired infectious diarrhea. The research aims to advance...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $249,000.00 to the Regents of the University of Minnesota to define the mechanisms by which macrophages restrict the bacterium Klebsiella pneumoniae (KP) during bloodstream infections (bacteremia). The research aims to 1) understand how splenic macrophages restrict KP during bacteremia, 2) elucidate host pathways of KP...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $127,302 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Michigan. The grant, awarded on January 18, 2025, supports research to understand how the integrated stress response (ISR) in macrophages shapes the innate immune response and infection outcomes during Salmonella enterica serovar Typhi (STy) infection. The research aims to reveal the role of...