Project Grant R21AI190521
- The University of North Carolina at Chapel Hill received a $162,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on August 22, 2025. The grant will fund research to understand the mechanisms and parameters controlling gene amplification leading to phenotypic heterogeneity in Enterobacter bacteria, which can contribute to antibiotic resistance. The research aims to characterize the principles of gene...
- The University of North Carolina at Chapel Hill (UNC-CH) received a $498,885 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant, awarded on September 25, 2025, will support research to develop deep learning surrogate models that can predict the spread of antimalarial drug resistance, with a planned completion date of August 31, 2030. The research aims to...
- The University of North Carolina at Chapel Hill received a $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on May 13, 2025 to engineer non-replicating self-recirculating phages as a platform for gene therapy of the human microbiome. The project aims to develop methods that enable safe, efficient, and highly-targeted transduction of specific bacterial species within complex microbial...
- The University of North Carolina at Charlotte received a $413,542 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The funding supports research to develop novel non-immunostimulatory nanoparticle-carrier formulations that can deliver anti-inflammatory therapeutics or antimicrobial agents into resident central nervous system cells. The goal is to limit intracellular...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $402,284 to the University of North Carolina at Charlotte (UNC Charlotte) from August 18, 2025 to July 31, 2027. The goal of the project is to augment the host innate immune response against staphylococcal osteomyelitis, a severe bone infection caused by Staphylococcus aureus, through the use of antimicrobial nucleic...
- This Project Grant award of $115,123 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to reveal strategies for eradicating antibiotic-tolerant Staphylococcus aureus persister cells. The research aims to identify the host cells harboring intracellular S. aureus reservoirs and characterize the host and bacterial transcriptomes using single-cell approaches. Additionally, the project...
- This $427,625 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) with a period of performance from July 1, 2025 to June 30, 2027. The grant supports research at the University of North Carolina at Chapel Hill to elucidate the role of fimbriae (hair-like surface appendages) in Klebsiella pneumoniae-mediated liver abscess formation. The goal is to investigate the specific...
- This $427,625 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the causes of treatment failure for hypervirulent Klebsiella pneumoniae liver abscesses. The research aims to visualize antibiotic distribution and the role of antibiotic-tolerant bacterial cells in this treatment failure, as well as examine the transcriptional profile of the bacteria in...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $521,030.00 to the University of North Carolina at Chapel Hill to conduct research on the role of phenotypic heterogeneity in the fitness of Clostridioides difficile, a leading cause of antibiotic-associated disease. The goal is to define the interplay between stochastic and regulatory mechanisms underlying the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $759,983.00 to the University of North Carolina at Chapel Hill to conduct research on the role of neutrophils in lung infections and acute lung injury. The study aims to examine changes in neutrophil transcriptomes and function during Streptococcus pneumoniae pneumonia, with the goal of improving understanding of the lung's immune response and potential...
The University of North Carolina at Chapel Hill (UNC-CH) was awarded a $421,067 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on determining how neutrophil activities contribute to antibiotic treatment failure. The project aims to dissect the role of neutrophil extracellular traps (NETs) in promoting antibiotic tolerance in Staphylococcus aureus infections, evaluate the mechanisms by which neutrophils induce antibiotic tolerance, and investigate the impact of inhibiting neutrophilia and netosis on the efficacy of antibiotics in a murine bacteremia infection model. This research seeks to advance scientific understanding of antibiotic resistance and tolerance, with the goal of developing targeted interventions to improve the treatment of serious bacterial infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $421.1k | 8/8/25 |