This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $427,625 to the University of North Carolina at Chapel Hill to investigate the role of Klebsiella pneumoniae fimbriae in liver abscess formation. The project aims to elucidate how the type 1 and type 3 fimbriae, which are surface-expressed protein appendages, contribute to the pathogenesis of hypervirulent Klebsiella pneumoniae (HVKP) strains that can cause severe infections, including liver abscesses, in otherwise healthy individuals. The research will involve constructing and evaluating HVKP strains lacking these fimbriae to determine their importance in liver colonization and abscess formation, with the goal of identifying potential targets for novel anti-virulence therapies. The project period runs from July 1, 2025, to June 30, 2027.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $427.6k | 7/1/25 |