Project Grant R21AI190273

Award Date 7/1/25
Completion Date 6/30/27
Dollars Obligated $428K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
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The University of North Carolina at Chapel Hill was awarded a $427,625 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to study the factors contributing to treatment failure of hypervirulent Klebsiella pneumoniae liver abscesses. The research aims to: 1) use quantitative and imaging mass spectrometry to visualize antibiotic distribution and the role of antibiotic-tolerant cells in treatment failure, and 2) employ...
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This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $427,625 to the University of North Carolina at Chapel Hill to investigate the role of Klebsiella pneumoniae fimbriae in liver abscess formation. The project aims to elucidate how the type 1 and type 3 fimbriae, which are surface-expressed protein appendages, contribute to the pathogenesis of hypervirulent Klebsiella pneumoniae (HVKP) strains that can cause severe infections, including liver abscesses, in otherwise healthy individuals. The research will involve constructing and evaluating HVKP strains lacking these fimbriae to determine their importance in liver colonization and abscess formation, with the goal of identifying potential targets for novel anti-virulence therapies. The project period runs from July 1, 2025, to June 30, 2027.

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