Project Grant R01AI190302
- The University of North Carolina at Chapel Hill received a $162,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on August 22, 2025. The grant will fund research to understand the mechanisms and parameters controlling gene amplification leading to phenotypic heterogeneity in Enterobacter bacteria, which can contribute to antibiotic resistance. The research aims to characterize the principles of gene...
- The University of North Carolina at Chapel Hill (UNC-CH) was awarded a $421,067 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on determining how neutrophil activities contribute to antibiotic treatment failure. The project aims to dissect the role of neutrophil extracellular traps (NETs) in promoting antibiotic tolerance in Staphylococcus aureus infections, evaluate...
- The University of North Carolina at Chapel Hill received a $233,250 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on May 13, 2025 to engineer non-replicating self-recirculating phages as a platform for gene therapy of the human microbiome. The project aims to develop methods that enable safe, efficient, and highly-targeted transduction of specific bacterial species within complex microbial...
- This Project Grant award of $1,553,810 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate a genomic surveillance approach for monitoring artemisinin resistance in Plasmodium falciparum malaria in Africa. The project aims to identify genetic mutations and altered biological functions associated with artemisinin resistance, which is a critical concern as resistance emerges...
- The University of North Carolina at Charlotte received a $413,542 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The funding supports research to develop novel non-immunostimulatory nanoparticle-carrier formulations that can deliver anti-inflammatory therapeutics or antimicrobial agents into resident central nervous system cells. The goal is to limit intracellular...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,937,578 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of North Carolina at Chapel Hill. The grant, awarded on August 18, 2025, supports the development of an ACE2 immunodecoy therapy for long-lasting immunoprophylaxis against SARS-CoV-2 variants and other zoonotic coronaviruses that target the human ACE2 receptor. The project aims to optimize the linkage...
- The University of North Carolina at Greensboro (UNC-G) received a $727,079 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The purpose of the 5-year grant, which began on September 10, 2025, is to conduct research on the behavioral, microbial, and chemical ecology of sand fly oviposition (egg-laying) site selection. This research aims to develop an attractive lure...
- This $122,597 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to analyze the function and antibody-mediated inhibition of the malaria vaccine candidate protein PF3D7_1136200. The project aims to characterize this promising but previously uncharacterized blood-stage malaria antigen, with the goal of advancing development of a highly efficacious malaria vaccine. The...
- The University of California, San Francisco (UCSF) was awarded a $675,962 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to characterize the interaction between human and vector behaviors in order to enhance the impact of malaria control interventions in Uganda. The project will integrate rigorous human behavioral and entomological monitoring data to elucidate...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $501,011.00 to the University of North Carolina at Chapel Hill to conduct research on biodegradable polymeric microparticles comprised of acetalated dextran and their ability to induce immune tolerance. The goal is to develop an antigen-specific tolerance therapy for autoimmune diseases, an alternative to general...
The University of North Carolina at Chapel Hill (UNC-CH) received a $498,885 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant, awarded on September 25, 2025, will support research to develop deep learning surrogate models that can predict the spread of antimalarial drug resistance, with a planned completion date of August 31, 2030. The research aims to address the global public health challenge posed by the recent emergence of artemisinin partial resistance in Africa, which threatens the effectiveness of malaria control strategies. The Project Grant funding will enable UNC-CH researchers to leverage deep neural networks trained on simulation data to create predictive models that can inform efforts to mitigate the potential spread of antimalarial drug resistance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $498.9k | 9/25/25 |