This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on elucidating the role of Akkermansia muciniphila in Group B Streptococcal (GBS) vaginal colonization and ascending infection. The $148,568 award will support research to investigate the specific mechanisms by which A. muciniphila promotes GBS interaction with human vaginal epithelial cells, potentially...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $162,000 in funding to the Rector & Visitors of the University of Virginia (UVA) from September 1, 2024 to August 31, 2026. The project aims to characterize a Type VII secretion system (T7SS) in Group B Streptococcus (GBS) and investigate its role in virulence and immune response. Key objectives include...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by Virginia Commonwealth University (VCU) to investigate how the intracellular bacterial pathogen Anaplasma phagocytophilum exploits the host cell process of regulated exocytosis for its own release and dissemination. The $436,144 award, granted on September 20, 2024, will fund a 3-year research project to examine the role of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $135,258 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Virginia Polytechnic Institute & State University (Virginia Tech) on September 13, 2024. The grant will fund research to determine the biochemical features of Treponema pallidum peptidoglycan and the identity of released muropeptides, as well as elucidate the role of released peptidoglycan in the pathogenesis of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $483,000.00 to Case Western Reserve University to conduct research on defining the role of single-cell heterogeneity in bacterial vaginosis (BV). The overarching goal is to identify aspects of diversity that impact BV and provide insights into new strategies for prevention, treatment, and diagnosis. The...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $533,750.00 to the University of Florida to study the role of macrophages in the increased HIV risk associated with bacterial vaginosis (BV). The research aims to determine how a non-optimal vaginal microbiome affects the activation and "training" of macrophages towards an HIV-permissive phenotype. This will be...
This $315,000 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will be used by the Regents of the University of California at Riverside to conduct research on the interactions between the vaginal virome and bacterial vaginosis (BV), as well as the impact on HIV acquisition risk. The study aims to characterize the vaginal virome and its role in BV...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 - Allergy and Infectious Diseases Research, is funding research to investigate the role of T cells and the cytokine IL-9 at the maternal-fetal interface in preterm labor and birth. The $1,096,566 award to Washington University aims to elucidate the mechanisms by which IL-9 promotes preterm birth, define the impact on offspring, and identify new T cell subtypes contributing to...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $453,750 to Tufts University School of Medicine to study how certain bacteriophages (viruses that infect bacteria) evade the protective mechanisms of bacteria, including some deadly pathogens like Vibrio cholerae. The project aims to determine the counter-defense mechanisms used by these phages and identify the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $450,630 to Tufts University School of Medicine to conduct research on the interactions between the bacterial pathogen Streptococcus pneumoniae, pulmonary epithelial cells, and neutrophils that contribute to age-associated susceptibility to pneumococcal disease. The objectives are to utilize advanced microscopy...