This federal Project Grant award of $453,429 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the regulation of RNA editing in two life cycle stages of the pathogenic kinetoplastid protozoan Trypanosoma brucei. The research aims to provide insights into the key proteins and mechanisms driving differential RNA editing across the parasite's life cycle, which alternates...
This three-year, $828,217 National Science Foundation project grant supports collaborative research on RNA processing in trypanosome mitochondria at Texas A&M Agrilife Research. Funded under the Biological Sciences program (CFDA 47.074), the award will advance understanding of gene expression regulation in the single-celled parasites that cause sleeping sickness. Specifically, the award funds three objectives investigating how mRNA editing is differentially controlled across the life cycle...
This three-year, five-hundred twenty-three thousand four-hundred sixty-one dollar project grant from the National Science Foundation's Division of Molecular and Cellular Biosciences will fund research into RNA processing in trypanosome mitochondria. The grant was awarded to Seattle Children's Research Institute on April 1, 2022 and will be completed by March 31, 2025. The project aims to advance understanding of gene expression regulation in trypanosomes, single-celled parasites that alternate...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $565,149 to Health Research, Inc. Wadsworth Center Division to conduct research on RNA-based regulatory mechanisms in Mycobacterium tuberculosis (MTB). The primary objectives are to: Define the regulatory interactions of the sRNA MCR11 and its impact on gene expression in MTB. Characterize the roles of RNA-ABMR...
This Project Grant award of $791,864, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify the molecular factors that control chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The primary goal is to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, and...
This $440,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training) supports two key research subprojects at the University of Texas Medical Branch at Galveston (UTMB): Developing a quantitative understanding of the mechanisms underlying contractile injection systems (e.g. phage tails, tailocins, type VI secretion systems) and how they breach bacterial cell envelopes. This research will inform the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $375,000.00 in funding to the University of South Florida to conduct research on the functions of messenger ribonucleoproteins (mRNPs) in regulating RNA metabolism in the malaria parasite Plasmodium falciparum. The key objectives of this 5-year research project are to: 1) identify molecular markers for distinct mRNP...
This Project Grant award of $416,165 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate blood fitness genes in the tsetse fly symbiont Sodalis glossinidius. The central hypothesis is that S. glossinidius requires specific genes to access nutrients and survive within the blood-rich tsetse fly gut environment. The research goals are to screen S. glossinidius transposon libraries for candidate...
This $636,101 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Texas Medical Branch at Galveston (UTMB). The goal of the 5-year award, starting on Nov 22, 2024, is to elucidate the mechanisms of viral RNA packaging and co-packaging in Rift Valley Fever Virus (RVFV), a high-priority pathogen and potential bioterrorism agent. The research aims to provide...
This $646,291 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate treatment outcomes and disease prevention strategies for Chagas disease, a parasitic infection caused by Trypanosoma cruzi. The project aims to compare the effectiveness of a new high-rate-of-cure treatment regimen delivered to dogs either shortly after infection or several years later....