Project Grant R21AI187749

Award Date 8/1/25
Completion Date 7/31/27
Dollars Obligated $262K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $891,678 to the Scripps Research Institute in La Jolla, CA to conduct research on how metabolites from the intestinal microbiota can modulate host immune responses. The researchers will employ chemical biology and proteomics methods to identify specific microbiota-associated bile acid protein targets in mammalian cells...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
This Project Grant award of $828,820 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research to elucidate the molecular mechanisms by which the commensal bacterium Enterococcus faecalis can translocate across the intestinal epithelial barrier and cause systemic infections. The research aims to define how E. faecalis disrupts endoplasmic reticulum proteostasis and activates the unfolded...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $222,852 to support research into the regulation of virulence factors in the pathogenic bacterium Clostridioides difficile. The primary objective is to identify and annotate Rho, NusA, and NusG dependent transcriptional terminators in C. difficile to understand how these regulatory factors influence the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,104 to Tufts University School of Medicine to conduct research on the impact of Clostridioides difficile's spatial distribution and toxin gene expression on disease severity. The researchers aim to use fluorescent reporter strains to visualize C. difficile cells and their toxin gene expression during murine...
This $926,057 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research is supporting research to understand how the gut microbiota influences immune responses, particularly B-cell development and antibody production, following vaccination. The project aims to identify gut stromal cell populations and microbial components that are crucial for enhancing stromal cell function and promoting improved...
This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $171,254 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Nimml Institute Inc., a 501(c)(3) non-profit research organization in Blacksburg, Virginia. The grant, effective from December 1, 2024 to November 30, 2026, aims to elucidate novel immunometabolic mechanisms that intercept bacterial toxin internalization and processing to suppress cell damage caused by Clostridioides difficile...
This $531,245 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research by Yale University to structurally and functionally characterize the sorting platform component of the type III secretion system (T3SS) in Salmonella bacteria. Through a multidisciplinary approach involving bacterial genetics, biochemistry, microscopy, and cryo-electron microscopy, the research aims to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $219,122 to the University of Illinois to conduct research on Salmonella Typhimurium infection. The goal is to understand the mechanisms of gene regulation that control the bacteria's ability to infect and colonize host cells. The research focuses on characterizing a novel small RNA-mediated regulatory system that...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) is focused on understanding how the commensal bacteria Turicibacter sanguinis can protect against severe diarrheal disease caused by the intestinal pathogen Citrobacter rodentium. The $262,410 award, with a project period from Aug 1, 2025 to Jul 31, 2027, will support research at Vanderbilt University Medical Center to investigate the role of specific intestinal metabolites in modulating pathogen severity, and how T. sanguinis may confer resistance by altering these metabolite levels. The goal is to identify potential therapeutic strategies for preventing and treating bacterial diarrheal diseases, which are a leading cause of child mortality worldwide.

Generated 8/5/25, 5:35 AM