This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $254,250 to New York University (NYU) from July 1, 2025 to June 30, 2027. The funding supports research to understand how pathogenic alphaviruses, such as chikungunya virus, infect and spread through human microvascular endothelial cells. The research aims to identify viral and host factors that restrict alphavirus...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $805,375 to the Icahn School of Medicine at Mount Sinai to conduct research on the tropism and pathogenesis of pararubulaviruses. The key objectives are to: 1) define the cellular tropism of Menangle and Sosuga viruses in human cells, 2) characterize the receptor usage pathways of these viruses, and 3)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $147,486.00 to the Icahn School of Medicine at Mount Sinai to conduct high-resolution immunological characterizations of a novel murine model of chronic hepacivirus infection. The goal is to study the evolution of immune dysfunction over the course of infection and better understand the molecular drivers of T cell exhaustion and viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $256,995.00 to Tufts University School of Medicine to develop a generalizable strategy for linking quantitative measures of pathogen traits, such as fitness and iron starvation, to host cell mutations using optical sequencing. The project aims to overcome limitations in current approaches for evaluating...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
This Project Grant award, valued at $792,687.00 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to define the structural features of sialoglycans necessary for influenza A virus (IAV) infection and adaptation across various host species. The key activities under this award include: 1) using CRISPR/Cas9 techniques to truncate different types of sialoglycans in human lung...
This Project Grant award of $1,454,386.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports fundamental research to better understand the epigenetic regulation of the HIV-1 viral RNA cap. The research aims to define the structural basis of HIV cap hypermethylation and its linkage to modulating host innate immune signaling, with the goal of developing new treatments to neutralize deleterious...
The federal Project Grant award R21AI185033 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of the APOBEC3B enzyme in the innate immune response against RNA viruses such as SARS-CoV-2, HIV-1, and Hepatitis B. The $228,435 award, effective January 2, 2025 through December 31, 2026, will fund research at the University of California, Irvine to identify novel...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) totaling $237,165 to the Research Foundation for the State University of New York (RFSUNY), doing business as SUNY Downstate Health Sciences University. The grant, effective from November 14, 2024 to October 31, 2026, will support research to elucidate the molecular mechanisms of viral internal ribosomal entry site (IRES)-mediated translation...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research on manipulating the DNA damage response and proteome on viral genomes during herpes simplex virus (HSV) infection. The $651,832 award, with a project period from November 2024 to October 2029, will enable researchers at The Children's Hospital of Philadelphia to conduct a multi-modal proteomic...