Project Grant R21AI187620
Award Date 7/25/25
Completion Date 6/30/27
Dollars Obligated $437K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
Similar Awards
- This $2,976,652 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), aims to explore how polyamines impact methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two dangerous human skin pathogens. The research will investigate how these pathogens develop resistance to polyamines, which are highly toxic to them, and seek to develop novel synthetic...
- This Project Grant award of $115,123 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to reveal strategies for eradicating antibiotic-tolerant Staphylococcus aureus persister cells. The research aims to identify the host cells harboring intracellular S. aureus reservoirs and characterize the host and bacterial transcriptomes using single-cell approaches. Additionally, the project...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This federal Project Grant award of $481,214 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to define high-risk genomic groups of the bacterium Stenotrophomonas maltophilia. The research aims to investigate how different genomic groups of S. maltophilia may impact clinical presentation and patient outcomes, as prior studies have identified certain genomic groups associated...
- The University of Pittsburgh received a Project Grant award of $397,500.00 on September 4, 2025 from the National Institutes of Health (NIH) under the Biomedical Research and Research Training program (CFDA 93.859) to study the evolution and adaptation of Staphylococcus aureus to nutrient stress. The research aims to understand how S. aureus adapts and evolves in response to the nutrient stress imposed by the host environment during infection. The long-term vision is to use this knowledge to...
- This $226,253 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the host protein ADAM10 modulates the interactions between neutrophils and the endothelium during Staphylococcus aureus infection. The project aims to generate a spatiotemporal analysis of these key cellular and molecular interactions in the early stages of infection, leveraging...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,121,542 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Johns Hopkins University. The purpose of this 4-year project, starting on August 1, 2025, is to develop and utilize animal models and novel positron emission tomography (PET) imaging techniques to study Staphylococcus aureus (S. aureus) orthopedic implant-associated infections. This research aims to...
- This Project Grant award of $3,210,845.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to develop methods for the real-time detection of Staphylococcus aureus transmission in hospital settings. The key products and services to be delivered under this award include: Integrating weekly patient colonization sampling with hospital-wide genomic surveillance to analyze phylogenetic relationships among S. aureus strains, in...
- The National Institute of General Medical Sciences (NIGMS) awarded a $405,015 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the Inter American University of Puerto Rico, Inc. (Metropolitan Campus) to investigate the mechanism of action of antibacterial synthetic unsaturated fatty acids (UFAs) against methicillin-resistant Staphylococcus aureus (MRSA). The key objectives of this 3-year project are to determine if UFAs such as 2-hexadecynoic acid...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $447,783 to the University of Pittsburgh to conduct preclinical research on prosthetic joint infections (PJI) and the use of bacteriophage therapy as a novel treatment. The key objectives are to: 1) evaluate the clonality of S. aureus PJI infections using whole genome sequencing, 2) visualize biofilm...