Project Grant R21AI188355
- This Project Grant award of $427,625.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to exploit bacteriophages (viruses that infect bacteria) to discover novel anti-biofilm agents. The goal is to improve phage therapy and identify proteins that could be developed as stand-alone therapeutics to treat biofilm-associated infections, which are a particular concern for the opportunistic pathogen Pseudomonas aeruginosa....
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $769,390 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, to research using ultrasound and microbubbles to augment antibiotic efficacy against periprosthetic joint infections. The project aims to sensitize bacterial aggregates to antibiotics through a combination of antibiotics and ultrasound-triggered...
- The Project Grant award of $197,646 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research to enhance the function of bacteriophages (viruses that attack bacteria) as a potential treatment for antimicrobial resistant bacterial infections. The award recipient, the University of California, San Diego (UCSD), will conduct experimental evolution studies to identify genetic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $3,121,542 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Johns Hopkins University. The purpose of this 4-year project, starting on August 1, 2025, is to develop and utilize animal models and novel positron emission tomography (PET) imaging techniques to study Staphylococcus aureus (S. aureus) orthopedic implant-associated infections. This research aims to...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $150,000 Project Grant to The Ohio State University to develop novel bacteriophage-based therapies to combat Pseudomonas aeruginosa and Candida spp. dual-species biofilms. The project aims to create combination treatments using antimicrobial peptides and phages, as well as genetically engineer P. aeruginosa phages to produce...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $593,860 Project Grant through the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Massachusetts (UMass) for the development of new polymer-phage conjugate nanoparticles to treat antibiotic-resistant wound biofilm infections. The 5-year project, which began on June 6, 2025, seeks to create phage-polymer nanoparticles that can effectively penetrate and eradicate biofilm infections...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This $2,976,652 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), aims to explore how polyamines impact methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two dangerous human skin pathogens. The research will investigate how these pathogens develop resistance to polyamines, which are highly toxic to them, and seek to develop novel synthetic...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $142,492 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Washington University in Missouri. The grant, titled "High Throughput Identification of Bacteriophages and Their Hosts with Single-Cell Transcriptomics," aims to establish an innovative, high-throughput phage-host pairing tool for rapidly screening complex, naturally occurring microbial...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate the role of a Pseudomonas bacteriophage (PF phage) in promoting chronic biofilm lung infections in individuals with cystic fibrosis. The $192,672 award, effective from September 1, 2025 to August 31, 2030, will support research at Stanford University to study how the PF phage mediates...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $447,783 to the University of Pittsburgh to conduct preclinical research on prosthetic joint infections (PJI) and the use of bacteriophage therapy as a novel treatment. The key objectives are to: 1) evaluate the clonality of S. aureus PJI infections using whole genome sequencing, 2) visualize biofilm formation on explanted prosthetics to determine biofilm locations, and 3) assess the efficacy of different routes of bacteriophage administration in reducing biofilm burden in a murine PJI model. This research aims to address gaps in knowledge to help develop effective bacteriophage treatment protocols for PJI, a serious complication of joint replacement surgery. The project period runs from August 2025 to July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $447.8k | 8/11/25 |