This R21 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $220,000 to support research at the Fred Hutchinson Cancer Center (also known as the Seattle Cancer Care Alliance) investigating natural killer (NK) cell memory responses to HIV. The key goals of this research project are to identify and characterize HIV-specific NK memory cell clones using a novel single-cell barcoding technique called ASAP-SEQ. Researchers will examine longitudinal samples from an HIV-infected cohort to detect new NK memory clones that arise after HIV acquisition, while controlling for the potential confounding effects of co-infection with cytomegalovirus (HCMV). If successful, this innovative work could provide fundamental insights into NK cell-mediated immune responses against HIV, laying the groundwork for future studies to harness these responses for HIV prevention and treatment.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $220.0k | 5/22/25 |