Project Grant K08AI183990

Award Date 8/5/24
Completion Date 7/31/29
Dollars Obligated $186K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
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  1. Characterize and overcome the inhibitory effects of soluble HIV antigen on CD4CAR T-cell function using new ex vivo models of viremia.
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  3. Develop and validate potent "armored" CD4CAR T-cell constructs with improved function and persistence during viremia in a non-human primate model of chronic HIV infection.

The grant will support the research and development efforts of Dr. Bui at the University of Washington, a leading institution in adoptive cellular therapies and infectious disease research, as he transitions to an independent physician-scientist role. The project aims to advance the viability of CD4CAR T-cell immunotherapies as a potential functional cure for HIV.

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