This $812,810 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at Emory University to generate highly differentiated natural killer (NK) cells and evaluate their synergistic effects with broadly neutralizing antibodies in reducing the SIV reservoir and establishing viral control in the absence of antiretroviral therapy (ART).
The key objectives are to: 1) define...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $217,350 to Duke University to conduct research on harnessing CD89+ natural killer (NK) cells for novel therapeutic interventions against HIV/SIV. The project aims to:
Characterize the role(s) and functional regulation of CD89+ NK cells in the mucosae in normal and SIV/SHIV-infected macaques.
Investigate the role of autologous CD89+...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,761,680.00 to Emory University to evaluate the safety and therapeutic potential of a novel strategy towards a cure for HIV infection. The proposed treatment combines soluble IL-15/IL-15RA with a TGF-β pathway blockade and therapeutic vaccination to enhance and restore the function of anti-viral immunity, with the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $243,713 to the University of Massachusetts Medical School to conduct research on how HIV-infected macrophages evade antibody-dependent cellular cytotoxicity (ADCC) mediated by natural killer (NK) cells. The research aims to characterize the effects of specific HIV accessory proteins on ADCC-triggered NK cell signaling towards infected CD4+...
This federal Project Grant award in the amount of $1,179,316.00 was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award is focused on understanding the mechanisms that regulate CD8 T cell responses during chronic viral infection, with the goal of improving immunotherapies to increase T cell function and reduce viral load. Key aspects of the research include:
Determining the role of...
This $1,617,200 federal Project Grant award, issued by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program), supports research to investigate the immune microenvironments that impact HIV persistence and expression during antiretroviral therapy. The research aims to determine the location, phenotype, and microenvironment of HIV RNA-expressing cells in secondary lymphoid tissues of people with HIV on prolonged antiretroviral...
This federal Project Grant award of $500,475.00, administered by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research), supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to investigate the host-dependent mechanisms that guide the longitudinal dynamics of SIV (Simian Immunodeficiency Virus) integration. The research project aims to generate an atlas of SIV integration sites and characterize the impact of host...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of immunoglobulin genetic diversity in the development of neutralizing antibodies against the HIV envelope protein. The $144,362 award to Emory University, with a performance period from August 2024 to February 2027, aims to identify genetic polymorphisms in rhesus macaques...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of cells, antigens, and antibodies in controlling virus infections through antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The $318,085 award, running from December 2024 to November 2029, aims...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA Program 93.855 - Allergy and Infectious Diseases Research - totals $718,758 over the period of September 1, 2024 to August 31, 2025. The grant aims to explore the use of an IL-21-IgFc fusion protein as a host-directed immunotherapy to enhance immunity in individuals with tuberculosis (TB)/HIV co-infection. Specifically, the research will investigate whether supplementing...