Project Grant R21AI186052
- This Project Grant award of $684,937.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the role of the junctophilin-1 (JP1) protein in cardiac function and heart failure. The research project is being conducted at The University of Iowa, a prominent public research university with extensive experience in federal contracting and grant work. The project aims to dissect the function of JP1...
- The federal Project Grant award of $651,009 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Iowa to investigate the role of the protein junctophilin-2 (JP2) in regulating calcium signaling in cardiac fibroblasts and its impact on cardiac fibrosis. The project aims to employ advanced molecular, physiological, and biochemical techniques, along with innovative mouse models, to elucidate the specific...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $811,885 in funding to the J. David Gladstone Institutes in California to conduct research on epigenomic mechanisms of cardiac fibrosis and heart failure. The project aims to investigate the role of the MEOX1 gene as a key transcriptional regulator of fibroblast activation, fibrosis, and heart failure pathogenesis. The research leverages novel genetic mouse...
- The Project Grant award titled "STRESS-INDUCED TRNA-DERIVED SMALL RNAS IN CARDIAC FIBROSIS" is funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) in the amount of $739,474.00. The award, with a performance period from August 18, 2025 to May 31, 2030, supports research conducted by The General Hospital Corporation (Massachusetts General Hospital) to investigate the anti-fibrotic roles of a tRNA-derived small RNA (ASP-GTC-3'TDR) in...
- The University of Arizona was awarded a $625,316 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of RNA methylation and translational regulation in the oxidative stress response of heart failure. The research aims to elucidate how the YTHDF2 protein binds to methylated NRF2 mRNA to selectively induce its translation under oxidative stress, a process that may be impaired in end-stage heart failure. The...
- The U.S. National Heart, Lung, and Blood Institute awarded a $803,768 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the J. David Gladstone Institutes, a non-profit biomedical research organization in California. The grant funding supports a research project titled "Chromatin Regulation of Immune Cells in Myocardial Inflammation", which aims to elucidate the role of the epigenetic regulator BRD4 in controlling monocyte differentiation and macrophage...
- This Project Grant award of $576,786.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at the University of Arizona to investigate the role of the YTHD2 protein in regulating the translation of the NRF2 protein under conditions of oxidative stress. The research aims to elucidate the mechanisms by which certain proteins, like NRF2, can continue to be translated despite the general inhibition of protein...
- This Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to investigate the interaction between the proteins MG53 and GSDMD and their role in preventing neutrophil pyroptosis, which can contribute to inflammation and heart cell damage after myocardial infarction. The $155,463 award will fund research with two main objectives: 1) studying how MG53 and GSDMD interact before and after...
- The Project Grant award of $515,387 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research CFDA program (93.855) supports research to elucidate how long 3' untranslated regions (UTRs) of RNA form and cause autoinflammation. The project aims to investigate the role of neuronal RNA structures, particularly long double-stranded RNAs (dsRNAs), in triggering inflammation through pattern recognition receptors. Specifically, the...
- This Project Grant award for $727,710.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance understanding of the mechanisms driving arrhythmogenic cardiomyopathy, a genetic heart disease that can cause sudden death in young people. The award supports research at the University of California, San Diego (UCSD) to develop preclinical mouse models exhibiting inflammation and T-cell mediated immune responses as key drivers of this...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) for $283,250, awarded on Aug 19, 2025, supports research to investigate the role of self-RNA immunogenicity in heart failure associated with Junctophilin-2 (JPH2) deficiency. The research aims to determine how JPH2's newly identified function as a double-stranded RNA (dsRNA) binding protein contributes to cardiac pathology, and whether dsRNA binding induces structural changes in JPH2 that impact its role in calcium-induced calcium release within cardiomyocytes. The project will leverage mouse models and synthetic proteins to study these mechanisms, with the goal of redefining JPH2's function in cardiac biology and identifying potential therapeutic targets for cardiomyopathy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $283.3k | 8/19/25 |