Project Grant R21AI183000

Award Date 7/10/25
Completion Date 6/30/27
Dollars Obligated $223K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Illinois, USA
Similar Awards
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,336,490 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The 5-year grant, awarded on August 6, 2024, supports research to understand B cell and antibody responses to placental versus foreign antigens, with the goal of illuminating how dysregulated responses contribute to pregnancy complications and informing...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, provides $156,080 to the University of Utah to conduct research on how natural killer (NK) cells function and recognize different peptides. The goal is to determine how the inhibitory receptor LY49C allows NK cells to display differential effector functions when presented with different peptides, without direct contacts...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $220,000 to the Fred Hutchinson Cancer Center to conduct research on natural killer (NK) cell memory responses to HIV. The key objectives are to use a novel lineage tracing method called ASAP-seq to identify and characterize long-lived, HIV-specific NK memory cell clones in a unique longitudinal cohort of...
This Project Grant award of $666,567 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Los Angeles (UCLA) to investigate the transcriptional regulation of human natural killer (NK) cell function in response to viral infections, such as human cytomegalovirus (HCMV). The key objectives are to determine the mechanisms by which the transcription factor MEF2C regulates NK cell...
This Project Grant award, totaling $764,591, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The project aims to study the differential regulation of cell cycle entry and apoptosis in cytolytic lymphocytes, particularly natural killer (NK) cells, with a focus on understanding how genetic variants affecting DNA replication (the "replisome") can impair NK cell function. The...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $3,519,992 to the Sloan-Kettering Institute for Cancer Research to conduct research on the chromatin architecture regulating trained immunity in antiviral natural killer (NK) cells. The 4-year project aims to investigate how the 3D genomic landscape and chromatin organizers impact the development of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under CFDA 93.855 - Allergy and Infectious Diseases Research, provides $109,671.00 to the University of Massachusetts Medical School (UMass Medical) to characterize mechanisms by which HIV-infected macrophages resist natural killer (NK) cell-mediated killing. The research aims to define macrophage-specific mechanisms that increase resistance to NK cell-mediated killing, focusing on: 1)...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $848,839 to the University of Massachusetts Medical School (UMass Medical) to investigate new mechanisms by which HIV accessory proteins mediate control of natural killer (NK) cell function. The key objectives are to identify novel HIV-regulated NK cell ligands, define how the HIV Vif protein regulates MHC-I...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $131,268 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to George Washington University (GWU). The grant supports research to evaluate the role of the PTPN1 and PTPN2 phosphatases in regulating natural killer (NK) cell function against HIV. The project aims to assess the impact of inhibiting these phosphatases, either pharmacologically or through CRISPR gene editing, on enhancing...
This $649,053 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports research by The Washington University to investigate the role of Ly49 family receptors on CD8 T cells. The central hypothesis is that immunization expands the sub-population of CD8 regulatory T cells (Tregs) that can resolve immune responses, and that Ly49 and the transcription factor Helios...

The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $223,068 Project Grant to Loyola University of Chicago to investigate the origin, differentiation, and function of tissue-resident natural killer (NK) cells in the uterine mucosa. The 2-year project, running from July 2025 to June 2027, aims to elucidate the signals that drive the differentiation of circulating NK cells into specialized tissue-resident NK cells, and determine the role of progesterone in modulating the cytotoxicity of these cells to contribute to fetal tolerance during pregnancy.

Generated 8/5/25, 5:20 AM