Project Grant R21AG104695
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,898 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct functional genetic analyses of healthspan in humans. The recipient will identify shared genetic architecture underlying age-related diseases and aging-related traits, experimentally validate the regulatory roles of healthspan-associated non-coding variants and their target genes, and elucidate molecular...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $450,200 on May 15, 2026, under the Aging Research program (CFDA 93.866) to map age-dependent changes in primary sensory neurons and nociceptors. The recipient will deliver a systematic, cell-type-resolved map of how normal aging remodels peripheral sensory neurons housed in the dorsal-root ganglion (DRG). The project employs subtype-specific labeling via a recently published molecular-genetic...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which NBR2, a long non-coding RNA, contributes to ovarian aging. The research addresses female-specific health conditions through genome-wide association studies and functional genomic studies in human ovarian cell models. The...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $152,300 to The Salk Institute for Biological Studies on August 6, 2026, under the Aging Research program (CFDA 93.866). The award is a Project Grant (F32AG099471). The recipient will conduct research using a murine influenza infection model to characterize age-related changes in disease tolerance mechanisms—the physiological defenses organisms deploy to survive infection without necessarily reducing...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
The National Institute on Aging, under the Department of Health and Human Services, awarded $467,181 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how a life history of physical trauma contributes to aging and markers of aging, including inflammatory response and epigenetic markers, using African killifish (Nothobranchius furzeri) as a model organism. The research will test whether single or multiple exposures to different types of injury stress during adulthood accelerate the onset or progression of aging markers, with focus on inflammation, stem cell dysfunction, and cellular senescence. The study will also examine whether injury survivors exhibit shortened lifespans relative to uninjured controls. African killifish provide a genetically tractable model with a short natural lifespan of four to six months, enabling testing of the hypothesis that injury stress accelerates aging in a timeframe and at a cost that would be prohibitively expensive, labor-intensive, and time-consuming in other vertebrate models. Performance occurs at Columbia University's Health Sciences Division in New York, New York. The period of performance runs through August 31, 2028. The award is classified as a Project Grant, an assistance type supporting biomedical research directed toward understanding the aging process and diseases affecting aging populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/26 | ||
| Not listed | $467.2k | 8/21/26 |