Project Grant R21AG104288
- The National Institute on Aging awarded the University of California, San Diego $439,750 under Project Grant R21AG100440 on May 1, 2026, to investigate the molecular mechanisms of nucleophagy and its role in chronological aging. The research focuses on defining the function of a novel nuclear envelope component identified through genetic screening that regulates autophagic degradation of the outer nuclear membrane protein HMG1. The investigator will test this component's effects across...
- Federal Project Grant Award Summary The University of California, San Diego received a $437,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds biomedical research investigating NEK7 (NIMA-related kinase-7) as a potential suppressor of inflammation in aging hearts through regulation of RNA-binding proteins. The research addresses the critical connection between...
- The National Institute on Aging awarded Cincinnati Children's Hospital Medical Center $445,500 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct proteomic research on nuclear rupture-associated proteins in laminopathy hearts. The award funds systematic identification of proteins recruited to nuclear rupture sites in cardiomyocytes, using laminopathy-related dilated cardiomyopathy as a disease model. Work includes in vivo proximity labeling to identify candidate...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded the University of California, San Diego $408,012 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop methods for improving central nervous system pharmacokinetics of targeted protein degraders through specialized assay workflows and prodrug chemistries. The research will establish dual-functional molecules that hijack endogenous molecular transport pathways to cross the blood-brain barrier, with early-stage application to...
- The National Institute on Aging awarded Montana State University $398,750 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate translatomic changes during cardiac aging, specifically the role of ribosomal protein RPL13 and translation initiation factors in reshaping cardiac proteomic composition and aging phenotypes. The project examines how alterations in ribosomal protein subunits reprogram the cardiac translatome and influence proteostasis during aging....
- The National Institute on Aging awarded the University of Tennessee Health Science Center $624,442 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic regulation of heart function in health and aging. The research examines the role of KDM6A, a histone demethylase, in normal heart function and aging-related heart injury. The project pursues two specific aims using state-of-the-art molecular approaches to identify novel mechanisms underlying aging-associated...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $435,875 to Vanderbilt University on May 15, 2026, under the Aging Research program (CFDA 93.866) to define characteristics of a resilient organelle interactome during aging. The research applies advanced 3D electron microscopy and artificial intelligence-based image analysis to map organelle interactions in Caenorhabditis elegans model organisms across the aging process. The work compares age-dependent...
- The National Institute on Aging awarded Albert Einstein College of Medicine $462,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate chaperone-mediated autophagy in aging-associated cardiovascular fibrosis. The research examines the role of declining chaperone-mediated autophagy (CMA) activity in fibroblasts as a driver of progressive fibrotic remodeling in aging hearts and vessels. The study will test whether age-related CMA decline in cardiac fibroblasts...
The National Institute on Aging awarded the University of California, San Diego $440,000 on August 15, 2026, for Project Grant R21AG104288 under the Aging Research program (CFDA 93.866). The award funds research defining the role of ATG9B protein in cardiac aging and mitochondrial dysfunction in cardiomyocytes. The work investigates how ATG9B regulates mitochondrial morphology and quality control in aging hearts, with preliminary findings showing that ATG9B levels decline in aging mouse hearts coinciding with abnormal mitochondrial elongation. The research seeks to identify molecular mechanisms underlying mitochondrial health decline in aging cardiomyocytes to inform therapeutic strategies for preserving heart function in elderly populations. Work is performed in La Jolla, California with a period of performance extending through July 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/12/26 |