Project Grant R21AG104135
Award Date 9/15/26
Completion Date 8/31/28
Dollars Obligated $399K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Bozeman, MT, USA
Similar Awards
- The National Institute on Aging awarded The Scripps Research Institute $645,242 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on chemical modulation of proteostasis to promote longevity and healthy aging. The award funds development of chemical and computational tools to selectively attenuate polysome-mediated translation in vivo, quantify protein conformational changes across the neuronal proteome with age, and assess healthy aging and behavior in...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- The National Institute on Aging awarded the University of Missouri System $429,394 on December 15, 2025, under the Aging Research program (CFDA 93.866) to investigate LARP6 as a druggable target for aging-associated heart failure with preserved ejection fraction (HFPEF) in co-morbid conditions including obesity and hypertension. The research examines how LARP6, an RNA binding protein implicated in pathologic cardiac fibrosis, regulates collagen messenger RNA stability and translation....
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded Albert Einstein College of Medicine $462,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate chaperone-mediated autophagy in aging-associated cardiovascular fibrosis. The research examines the role of declining chaperone-mediated autophagy (CMA) activity in fibroblasts as a driver of progressive fibrotic remodeling in aging hearts and vessels. The study will test whether age-related CMA decline in cardiac fibroblasts...
- The National Institute on Aging awarded the University of California, San Diego $440,000 on August 15, 2026, for Project Grant R21AG104288 under the Aging Research program (CFDA 93.866). The award funds research defining the role of ATG9B protein in cardiac aging and mitochondrial dysfunction in cardiomyocytes. The work investigates how ATG9B regulates mitochondrial morphology and quality control in aging hearts, with preliminary findings showing that ATG9B levels decline in aging mouse hearts...
- The National Institute on Aging awarded the University of Tennessee Health Science Center $624,442 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic regulation of heart function in health and aging. The research examines the role of KDM6A, a histone demethylase, in normal heart function and aging-related heart injury. The project pursues two specific aims using state-of-the-art molecular approaches to identify novel mechanisms underlying aging-associated...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded the University of Wisconsin System $698,690 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the molecular mechanisms of fiber type-specific skeletal muscle dysfunction with aging. The research quantifies proteome changes associated with fiber type-specific atrophy in older males and females, determines cross-bridge mechanisms for fiber type-specific impairments in contractile function, and identifies fiber...