Project Grant R21AG102421
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania a Project Grant of $333,116 under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2026. This award supports biomedical research directed toward understanding aging processes and age-related diseases. The research project investigates the relationship between telomere dysfunction, aging, and intestinal stem cell (ISC) niche function, with the goal of...
- The National Institute on Aging awarded the University of Pennsylvania $2,809,832 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic mechanisms driving cellular aging and age-associated disease. The award funds four integrated research projects examining chromatin homeostasis ("chromostasis") and senescence-associated secretory phenotype (SASP) in aging tissues. The research hypothesizes that age-related epigenetic changes result from...
- The National Institute on Aging awarded $671,107 to Cedars-Sinai Medical Center on July 15, 2026, under the Aging Research program (CFDA 93.866) to investigate P53 acetylation as a driver of alveolar progenitor cell senescence in idiopathic pulmonary fibrosis. The recipient is conducting research into the mechanisms by which aberrant P53 activation, stabilized through acetylation and enhanced by increased CBP/P300 acetyltransferase activity and reduced SIRT1 expression, initiates and perpetuates...
- The National Institute on Aging awarded Baylor College of Medicine $651,838 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the regulatory mechanisms of periosteal skeletal stem cells (P-SSCs) in bone maintenance and repair with aging. The research addresses the clinical problem that bone healing capacity declines with age, creating significant healthcare burden from delayed healing and non-union in aged bone defects. The project will characterize the in vivo niche...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded the University of Pittsburgh $619,577 on September 1, 2026, under the Aging Research program (CFDA 93.866) for statistical methods development in spatial proteogenomics data analysis applied to Alzheimer's disease research. The project develops computational and statistical methods to advance spatial proteogenomics analysis, which integrates spatially resolved protein and transcript information to examine cellular organization in brain tissue. In Aim 1,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Old Dominion University $160,000 on September 1, 2026, to develop and test a three-dimensional bioprinted mammary model system for investigating age-related cellular dysfunction and regenerative microenvironment mechanisms under the Aging Research program (CFDA 93.866). The project addresses molecular mechanisms underlying cellular and tissue rejuvenation through a regenerative microenvironment model....
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Johns Hopkins University $427,625 for Project Grant R21AG102518 on September 1, 2026, under the Aging Research program (CFDA 93.866). The recipient will develop a human three-dimensional neuromuscular microphysiological system to model skeletal muscle aging ex vivo. The platform integrates primary human muscle stem cells from young (20–30 years) and aged (60–75 years) donors, induced pluripotent...
The National Institute on Aging awarded The Pennsylvania State University $432,575 under the Aging Research program (CFDA 93.866) on September 1, 2026, to develop a three-dimensional, ventilatable, bioprinted alveolar sac model derived from induced-pluripotent stem cell-derived alveolar epithelial type II cells and primary human lung resident mesenchymal stromal cells. The model will investigate how aging disrupts epithelial-mesenchymal interactions, cellular senescence, and epithelial repair mechanisms in the alveolar niche. The recipient will characterize the effects of donor age on mesenchymal stromal cell function and their signaling interactions with aging epithelial cells, with particular focus on extracellular matrix remodeling and tissue mechanics dysfunction. Work is performed in State College, Pennsylvania, with performance through August 31, 2028. The project builds on the recipient's prior success engineering a structurally and functionally native-like alveolar sac that exhibits discrete compartmentalization, apico-basal polarity for epithelial barrier integrity, surfactant production, and mechano-responsiveness, and extends that platform to model age-related epithelial dysfunction and impaired repair capacity in human-relevant systems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.6k | 8/21/26 |