Project Grant R21AG101044
- Federal Grant Award Summary Baylor College of Medicine received a $1.34 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on March 1, 2026, with a completion date of February 28, 2031. The award funds research utilizing DNA-encoded libraries (DELs) and machine learning (ML) to identify tool compounds and chemical probes targeting putative therapeutic compounds for Alzheimer's disease and Alzheimer's disease-related dementias. The...
- Federal Project Grant Award Summary Epicypher, Inc. received a $1.25M Project Grant award from the National Institute on Aging (CFDA 93.866: Aging Research) effective September 20, 2025, with completion targeted for May 31, 2027. In partnership with Dr. Nicolas Young at Baylor College of Medicine, Epicypher is developing AgingPTM™, a novel platform technology designed to identify and study aging-associated combinatorial histone post-translational modifications (HPTMs) in tissue samples. The...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pennsylvania a $2.8 million Project Grant under the Aging Research program (CFDA 93.866) for the five-year period from February 1, 2026, through January 31, 2031. The grant supports research on the epigenetics of aging and age-associated diseases, with particular focus on two mechanisms: chromostasis (homeostatic mechanisms that maintain dynamic chromatin stability) and the senescence-associated secretory...
- Federal Grant Award Summary Baylor College of Medicine received a $1.31M Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research program) awarded February 15, 2026, with a completion date of January 31, 2031. This award funds a randomized clinical trial investigating the efficacy of GlyNAC supplementation—a combination of oral glycine and N-acetyl-cysteine (NAC)—in promoting healthy aging among typical older adults. The research builds on prior NIH-funded pilot studies...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a Project Grant in the amount of $556,121 under the Aging Research program (CFDA 93.866) on January 15, 2026. The award supports research through December 31, 2030, conducted at the university's St. Louis, Missouri facility. The project investigates transgenerational epigenetic adaptation and longevity changes in response to repeated environmental stresses, utilizing Caenorhabditis elegans (C....
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $610,836 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, through May 31, 2030. This award supports research on the genetic dissection of mitochondrial-nuclear (mitonuclear) interactions in aging and neurodegenerative disease, with particular focus on Alzheimer's disease and related dementias (ADRD). The research leverages two key...
- The federal Project Grant award of $1,440,000.00 was provided by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The project, titled "Systematic Brain-Body Communication and Personalized Aging Trajectories," seeks to elucidate how aging affects brain-body communication at the individual level. The research will integrate an innovative single-whole-organism single-cell sequencing platform and cutting-edge machine...
- Federal Project Grant Award Summary Yale University received a $681,277 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with completion targeted for April 30, 2031. The research project, titled "Cell Size Inheritance and Innate Immune Memory," investigates the mechanisms by which immune cells enlarge without triggering senescence—a pathological state characterized by irreversible cell cycle arrest associated...
- Federal Grant Award Summary Baylor College of Medicine received a $3.04 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of July 31, 2029. The grant funds research investigating the relationship between SARS-CoV-2 (COVID-19) infection and the initiation and acceleration of Alzheimer's disease (AD) and related dementias (AD/RD), including Pick's disease, frontotemporal dementia, and...
- Federal Grant Award Summary The National Institute on Aging awarded a $708,137 Project Grant to New York University School of Medicine (Award Date: February 1, 2026; Completion Date: January 31, 2030) under the Aging Research program (CFDA 93.866) to develop and validate advanced technologies for probing the biophysical properties of aging cells. The project focuses on creating Genetically Encoded Multimeric Particles (GEMs)—self-assembling, genetically encoded probe particles that enable...
Baylor College of Medicine received a $440,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) with a performance period from May 1, 2026, through April 30, 2028. The project, titled "Beyond Genetics: Unveiling Epigenetic Drivers of Lifespan Heterogeneity Through Yeast Single-Cell Aging Atlases," will deliver research services focused on identifying epigenetic factors that contribute to lifespan variation in genetically homogeneous organisms, specifically budding yeast. The research will produce single-cell transcriptomic and epigenomic analyses using advanced technologies including 10X Genomics-based high-throughput single-cell RNA sequencing and ATAC sequencing (assay for transposase-accessible chromatin using sequencing) to characterize aging trajectories and molecular pathways underlying lifespan heterogeneity. This exploratory project will generate comprehensive aging atlases and unbiased molecular analyses examining mother-daughter cell lineages to identify lifespan predictors and sources of variation beyond genetic and environmental factors. The research outputs will contribute to the National Institute on Aging's mission to advance understanding of the aging process and age-related diseases through biomedical research, with potential implications for understanding fundamental mechanisms of aging applicable to broader populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 5/5/26 |