Project Grant R21AG100933
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Icahn School of Medicine at Mount Sinai a Project Grant of $463,625 under the Aging Research program (CFDA 93.866) for the period September 1, 2025, through August 31, 2027. The grant supports research investigating the effects of aging on the lung adenocarcinoma tumor microenvironment, with particular focus on understanding age-related variations in immunotherapy response. The project deliverables include: (1)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $1,746,856 on August 5, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research examining the role of senescent cancer-associated fibroblasts (SENCAFs) in breast cancer progression. The research project, with a completion date of April 30, 2030, will deliver scientific knowledge regarding age-related changes in the tumor microenvironment and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $1,022,471 Project Grant under the Cancer Biology Research program (CFDA 93.396) beginning July 1, 2025, and concluding June 30, 2030. The research project, titled "Recurrence and Resistance in the Aging Melanoma Microenvironment," will investigate the mechanisms underlying metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on how age-related...
- Federal Grant Award Summary Fred Hutchinson Cancer Center received a $785,867 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded June 1, 2026, with completion targeted for May 31, 2031. The grant supports epidemiological and mechanistic research examining Clonal Hematopoiesis of Indeterminate Potential (CHIP) in aging and exceptional longevity among older women. The project deliverables include analysis of approximately 10,000 older women from the...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Dana-Farber Cancer Institute, Inc. a Project Grant totaling $737,261 under the Aging Research program (CFDA 93.866), effective July 1, 2026, through March 31, 2031. This research initiative investigates the functional consequences of telomere maintenance gene variants, specifically TERT (telomerase reverse transcriptase) missense rare variants, and their role in age-related disease development. The project combines genetic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $393,750 to the University of California, Los Angeles (UCLA) on September 22, 2025, under the Aging Research program (CFDA 93.866) to conduct a prospective cohort study investigating how aggressive cancer treatments affect physical function in older adults with gastroesophageal cancer (GEC). The research will enroll patients aged 60 years and older who are initiating systemic treatment (chemotherapy,...
- Federal Grant Award Summary The University of Florida, Division of Sponsored Research, received a $383,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 15, 2025, through July 31, 2027. This research project focuses on characterizing age-related changes to the senescence-associated secretory phenotype (SASP) of thyroid tissue in papillary thyroid carcinoma (PTC). The deliverables include scientific research aimed...
- Federal Project Grant Award Summary H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $687,593 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on May 12, 2026, with an ultimate completion date of April 30, 2031. The research project investigates cysteine acquisition and utilization mechanisms in lung adenocarcinoma, challenging the current understanding of how tumor cells obtain cysteine. The project...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc., a Project Grant of $734,942 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This project addresses cardiovascular disease (CVD) risk in breast cancer survivors by generating novel DNA methylation biomarker data from the Pathways Study, a prospective cohort of 4,504 women diagnosed with...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $460,283 through the Aging Research program (CFDA 93.866) to conduct a two-year research project from September 1, 2025 through August 31, 2027. This Project Grant supports biomedical research directed toward understanding the aging process and age-related diseases, with the funded research examining the role of reverse electron transport (RET) inhibition in...
H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. received a $463,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research on the contribution of the aged alveolar niche to lung cancer evolution. The research project, which commenced June 15, 2026, and is scheduled for completion by May 31, 2028, investigates how aging-driven changes in the lung tumor microenvironment—specifically the accumulation of damaged alveolar epithelial cells known as alveolar differentiation intermediates (ADIs)—influence non-small cell lung cancer (NSCLC) progression and therapeutic resistance. The funded research utilizes cellular and molecular biology approaches to elucidate the mechanisms by which ADIs and associated niche signaling in aged lungs promote stem-like tumor states with enhanced chemotherapy resistance. The deliverables from this research program include scientific findings regarding age-dependent lung cancer evolution mechanisms, experimental validation of ADI-driven niche signaling in aged tumor microenvironments, and identification of potential therapeutic targets to address age-related disparities in lung cancer outcomes. This investigation directly supports the NIA's mission to advance understanding of aging-related diseases through biomedical research and contributes to closing knowledge gaps regarding how aging influences cancer progression and treatment efficacy across different age groups.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $463.4k | 6/11/26 |