Project Grant R21AG100440
- Federal Project Grant Award Summary The University of California, San Diego received a $437,375 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. The award funds biomedical research investigating NEK7 (NIMA-related kinase-7) as a potential suppressor of inflammation in aging hearts through regulation of RNA-binding proteins. The research addresses the critical connection between...
- Federal Grant Award Summary The University of California, San Diego received a $700,795 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period of February 1, 2026, through January 31, 2031. The award funds the development and deployment of REDCAT (Raman Enhanced Determination of Cell Atlas and Typing), an integrated research platform designed to map single-cell metabolic activity in complex tissues and identify transcriptional and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded UC San Diego a Project Grant totaling $498,366 (Award Date: September 1, 2025; Completion Date: August 31, 2027) under the Aging Research program (CFDA 93.866) to develop and validate a novel platform for single-cell analysis of biological aging biomarkers. The project focuses on designing and implementing arrays of bottomless microscopic conical wells with picoliter volumes to capture, immunolabel, and conduct...
- Federal Grant Award Summary The University of California, San Diego received a $439,750 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on May 15, 2026, with a completion date of April 30, 2027. The grant supports a two-year research project investigating changes in hippocampal coding of very large spaces from adulthood to senescence. The research addresses a critical gap in understanding how the dorsal and ventral hippocampus contribute to...
- Federal Project Grant Award Summary The University of California, San Diego received a $3.14 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded September 15, 2025, with an ultimate completion date of August 31, 2029. This research project delivers comprehensive analysis and characterization of human brain neuropeptidomes and their biosynthetic proteases in normal and Alzheimer's disease (AD) conditions. The primary research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco a Project Grant of $1,275,512 under the Aging Research program (CFDA 93.866) for the period June 1, 2025 through May 31, 2027. This award supports biomedical research directed toward understanding how progranulin (PGRN) species contribute to TDP-43 (TAR DNA-binding protein 43) accumulation and proteolysis in age-related neurodegenerative diseases, including...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $413,385 to the University of California, Berkeley, effective September 1, 2025, through August 31, 2027, under the Aging Research program (CFDA 93.866). The award funds biomedical research aimed at elucidating the structure-function relationship between TPP1 (telomere shelterin protein 1) and telomere length control through deep scanning mutagenesis. The research will comprehensively characterize TPP1...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $1,587,554 under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating mitochondrial deoxyribonucleic acid (mtDNA) compaction and its relationship to somatic mutation accumulation across the human lifespan. The research project, initiated on June 17, 2025, and scheduled for completion by April 30, 2030, will deliver scientific...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $460,283 through the Aging Research program (CFDA 93.866) to conduct a two-year research project from September 1, 2025 through August 31, 2027. This Project Grant supports biomedical research directed toward understanding the aging process and age-related diseases, with the funded research examining the role of reverse electron transport (RET) inhibition in...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Salk Institute for Biological Studies a Project Grant of $620,441 under the Aging Research program (CFDA 93.866), with an award date of February 15, 2026 and ultimate completion date of January 31, 2031. This research initiative focuses on characterizing activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determining the functional consequences of dorsal horn remodeling for...
The University of California, San Diego received a $439,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period May 1, 2026 through April 30, 2028. This award funds research investigating the molecular mechanisms of nucleophagy—the autophagic degradation of nuclear envelope regions—and its relationship to chronological aging. The research will employ genetic screening, biochemical analysis, and cellular imaging to characterize a novel nuclear envelope component's role in selective autophagy pathways, with particular focus on understanding how impaired nucleophagy contributes to premature cell death during aging. The project will deliver comprehensive research products including characterization of the target gene's functional specificity across autophagic degradation pathways, ultrastructural analysis of the nuclear envelope during nucleophagy, identification of protein interactions through coprecipitation studies, and quantitative assessment of the deletion mutant's effects on chronological aging using independent biochemical assays. These deliverables will advance scientific understanding of the mechanistic relationships between nuclear envelope dynamics, selective autophagy, and the aging process, contributing to the NIA's mission of identifying preventative and therapeutic approaches for age-related diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.8k | 4/28/26 |