Project Grant R21AG095841
- This federal Project Grant award of $404,792 from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) to Yale University supports fundamental research to investigate the mechanisms regulating telomere length, protection, and replication. The research project aims to determine how the human POT1 protein coordinates the recruitment of telomerase and the CTC1-STN1-TEN1 complex to telomeres in order to maintain telomere length. Additionally,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $448,961 to Telohealthdx LLC to develop a low-cost, accurate, and high-throughput DNA array and fluorescent in situ hybridization (FISH)-based method to measure the absolute lengths of individual telomeres. The goal is to create an improved diagnostic test for telomere-associated diseases, which are prevalent among the aging population and include conditions like dyskeratosis congenita, aplastic...
- This $333,116 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the impact of telomere dysfunction and natural aging on the intestinal stem cell niche. The goal is to examine how aging and acute telomere failure suppress stromal niche support for intestinal stem cells, contributing to intestinal phenotypes associated with aging and telomeropathies like dyskeratosis congenita. The research will utilize a novel mouse...
- This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded Kent State University a $546,146 Project Grant to study the structure, accessibility, and extension of telomeric overhangs. The five-year grant, running from February 1, 2025 to January 31, 2030, will utilize single-molecule fluorescence methods, cryo-electron microscopy, and ensemble techniques to investigate how the structure and stability of...
This federal Project Grant award of $413,385 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the structure-function relationship between the TPP1 protein and telomere length control. The award supports comprehensive experiments using deep scanning mutagenesis of TPP1 to characterize the effects of mutations on telomere length, with the goal of identifying mutations that drive changes in telomere length. The research also seeks to uncover the molecular mechanisms governing length-dependent extendibility by telomerase, by identifying and characterizing TPP1 separation-of-function mutations. This work is anticipated to be completed over a 2-year period from September 2025 through August 2027 at the University of California, Berkeley.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $413.4k | 9/3/25 |