Project Grant R21AG099768
- Federal Grant Award Summary The University of Miami, through its Office of Research Administration within the School of Medicine, received a $109,652.00 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 5, 2026, with a one-year completion date of September 4, 2027. This award funds research investigating T cell senescence-driven immune dysfunction in aging and HIV-positive populations. The research aims to elucidate the mechanisms by...
- Federal Project Grant Award Summary Vanderbilt University's Sponsored Programs Administration received a $435,875 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of May 15, 2026 and completion date of April 30, 2028. The project, titled "Defining Characteristics of a Resilient Organelle Interactome During Aging," will deliver advanced scientific research and analytical tools focused on understanding...
- Federal Project Grant Award Summary Award Overview Vanderbilt University Medical Center received a $242,489 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 2, 2025, for a project period extending through May 31, 2030. The award supports research examining the proteomic signature of dual decline—the concurrent deterioration of gait and cognitive function in older adults—a condition affecting an estimated 10.2% of the aging...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $149,889 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with a completion date of May 31, 2030. The award supports a discovery-focused research initiative to identify mechanistic associations between epigenetic bone age, frailty measures, and bone imaging findings using artificial intelligence (AI) and deep learning (DL) approaches. The...
- Federal Grant Award Summary Virscio, Inc. received a $291,913 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded September 20, 2025, with completion scheduled for September 19, 2026. The grant funds the development of epigenetic and senescent cell biomarkers derived from nonhuman primate (NHP) tissues to advance aging research and anti-aging intervention strategies. The research focuses on creating an epigenetic "clock"—a biomarker...
- Federal Grant Award Summary Vanderbilt University received a $105,627 Project Grant award dated August 5, 2026, from the National Institute on Aging under the Aging Research program (CFDA 93.866) to support research on clonal hematopoiesis caused by mosaic chromosomal alterations (MCAs). This NIH F30 fellowship grant funds investigative work examining how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $481,250 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2028. The award supports research directed toward understanding erythropoietin (EPO) competence in the kidney and identifying molecular signatures and markers associated with anemia in elderly populations. The project addresses anemia pathogenesis...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division, a Project Grant totaling $422,125 under the Aging Research program (CFDA 93.866). The award, effective June 1, 2026, through May 31, 2028, funds research investigating the roles of misfolded protein aggregates on latent viral reservoirs in simian immunodeficiency virus (SIV)-infected,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $1,587,554 under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating mitochondrial deoxyribonucleic acid (mtDNA) compaction and its relationship to somatic mutation accumulation across the human lifespan. The research project, initiated on June 17, 2025, and scheduled for completion by April 30, 2030, will deliver scientific...
- Federal Grant Award Summary Vanderbilt University received a $482,800 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for January 31, 2031. The award supports research to understand sphingolipid-dependent remodeling of mitochondria in aging cells. The research project will deliver scientific knowledge regarding mechanisms linking sphingolipid metabolism to mitochondrial dysfunction during aging, employing...
Funding Agency and Program: National Institute on Aging (NIA), Aging Research Program (CFDA 93.866) Award Details: $519,500 Project Grant awarded May 15, 2026, with completion date April 30, 2028 Products and Services Delivered: Vanderbilt University Medical Center will conduct a two-year research investigation examining epigenetic age acceleration (EAA) and its manifestation across immune cell populations in people living with and without HIV (PWH). The primary deliverable is scientific research using cryopreserved peripheral blood mononuclear cell (PBMC) samples from approximately 140 study participants across two age cohorts (younger: ages 30-39; older: ages 50+) to determine whether bulk-PBMC EAA measures predict clinical aging markers including frailty, cognitive performance, and comorbidity burden, as well as immunologic aging profiles measured through CD4 and CD8 subpopulation analysis. This research addresses the NIH priority of understanding biological mechanisms driving accelerated aging in PWH, who experience premature onset of age-related conditions including cardiovascular disease and cognitive decline. The anticipated research products will include peer-reviewed publications and scientific data advancing understanding of EAA as an objective biomarker for mechanistic and interventional studies targeting improved aging outcomes in HIV-positive populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $519.5k | 5/13/26 |