Project Grant R21AG095506
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant totaling $602,065.00 to the University of Maryland, Baltimore on March 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This award funds basic research investigating the molecular mechanisms by which sodium-glucose cotransporter 2 (SGLT2) regulates aquaporin-4 (AQP4), a water channel protein critical to brain...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore a Project Grant of $427,625 on July 17, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research through June 30, 2027, focused on developing a comprehensive toolbox to study proteome plasticity in brain endothelial cells. The research addresses critical gaps in...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Leland Stanford Junior University a Project Grant totaling $125,685 on August 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research and development of a bioactive material intervention to address post-stroke dementia, a significant complication affecting approximately 7 million stroke...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $1,366,056 Project Grant to Washington University, effective January 1, 2026 through December 31, 2030, under the Aging Research program (CFDA 93.866). The grant funds development of an innovative biocompatible fiber implant designed to enable long-term, multifunctional deep-brain imaging and manipulation in mouse models of Alzheimer disease. The implant integrates photoacoustic microscopy (PAM) and two-photon...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded a $589,154 Project Grant to the University of Maryland, Baltimore effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports the development and validation of Normalized Cerebrovascular Reactivity (NCVR) MRI imaging technology to improve detection of vascular contributions to cognitive impairment (VCI) in patients with small-vessel disease (SVD). The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $1,543,254 under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2030. This award funds research to develop and test the efficacy of a metacognitive strategy intervention designed to address Parkinson Disease (PD)-related cognitive decline. The research delivers a behavioral intervention product—the Multicontext (MC) approach—which...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Washington University a Project Grant totaling $231,264.00 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, with an award date of April 8, 2026, and ultimate completion date of March 31, 2031. This research project focuses on identifying and validating cerebroprotective drug targets in human stroke patients by collecting and...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $633,146 Project Grant effective August 4, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative addresses the identification of modifiable factors associated with vascular cognitive impairment and dementia (VCID) occurring after stroke, a...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Iowa a Project Grant of $582,252 on February 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The University of Iowa will develop predictive tools to forecast cognitive outcomes in stroke patients based on lesion location analysis. The research leverages the university's comprehensive lesion...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Missouri System a $622,881 Project Grant on August 5, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on novel mechanisms of metabolic reprogramming of reactive astrocytes and brain repair after focal cerebral ischemia (FCI). The five-year award extends through July 31, 2030, and is being...
The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a Project Grant of $649,688 under the Aging Research program (CFDA 93.866) on May 15, 2026, with a completion date of April 30, 2029. The award funds research on instrumented brain organoids transplantation for chronic stroke treatment, addressing the critical gap in therapeutic interventions for stroke survivors beyond the acute phase. The research employs a multidisciplinary approach integrating flexible bioelectronics with advanced imaging techniques to develop microinstrumented cortical organoid therapy that overcomes existing limitations in electrode rigidity, real-time monitoring, and neural integration in adult brains. The project delivers novel scientific research and technological innovations by leveraging flexible bioelectronics, in vivo electrophysiology, and intravital multiphoton imaging to create a dynamic platform for real-time monitoring and intervention of implanted cortical organoids. This research aims to establish systematic evidence regarding the effects of electrical stimulation on implanted organoids and their potential to restore functional recovery in chronic stroke patients, ultimately providing a restorative treatment option for the millions of stroke survivors currently lacking effective FDA-approved interventions to improve their neurological conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $649.7k | 5/15/26 |