Project Grant R21AG091653
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This $1,592,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Illinois to investigate the role of tau protein misfolding and hyperphosphorylation in Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a disruption of tau's normal scaffolding and signaling functions, leading to dysregulation of key kinases like CK2 and JNK. The research aims to define how...
- This Project Grant award of $758,744 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the mechanistic link between tau signaling and blood-brain barrier dysfunction in Alzheimer's disease (AD). The objective is to establish a mechanism-based intervention targeting amyloid-beta and tau to repair blood-brain barrier dysfunction and slow cognitive decline in AD models. The research will be conducted by the University of Kentucky Research...
- The University of North Carolina at Chapel Hill (UNC-CH) received a $424,095 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop a CRISPR/Cas13 gene therapy targeting the tau protein for the treatment of Alzheimer's disease and other tauopathies. The project aims to identify and validate optimal guide RNAs to deplete specific tau isoforms in neurons, and evaluate the therapeutic potential of this approach in preclinical Alzheimer's disease mouse...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $165,348.00 to the Rector & Visitors of the University of Virginia to investigate the cellular and molecular mechanisms by which hyperphosphorylated tau protein induces neurotoxicity and cognitive deficits. The research aims to characterize the effects of hyperphosphorylated tau oligomers on brain function using transcriptomic profiling and neurophysiology approaches. Specifically, the...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
- This $489,065.00 Project Grant awarded by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to the University of North Carolina at Chapel Hill (UNC-CH) will fund research to develop potentiated chip variants as therapies for alleviating tau pathology and neurodegeneration. The award period runs from July 1, 2025 to June 30, 2028. UNC-CH, through its Office of Sponsored Research, will conduct this advanced biomedical research project, leveraging...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of North Carolina at Chapel Hill (UNC-CH) will develop a multi-layer neural transport equation to jointly model the spreading of tau aggregates throughout the brain network and along the brain cortex. This will allow researchers to uncover the selective mechanism in multi-layer tau propagation in Alzheimer's disease. The $420,119 award, with a period of performance from September 1, 2025 to August 31, 2027, aims to advance scientific understanding of the dynamic process of tau spreading and facilitate early diagnosis through improved tau biomarkers. The University of North Carolina at Chapel Hill, a prominent public research university, will serve as the primary awardee for this project.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.1k | 8/26/25 |