The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...
This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is for the development and evaluation of a novel immuno-gene therapy approach using a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody. The key objectives are to: 1) generate and validate the TOC1-scFv-HaloTag-Proteasome Degradation Signal (PDS)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,015,163 to Baylor College of Medicine to develop and utilize a high-throughput in vivo CRISPR/Cas9 screening method to identify regulators of tau protein levels in the mouse brain. The overarching goal is to bypass labor-intensive cell-based screens and instead directly target brain-specific regulators in an in vivo model. This novel screening approach will be used to comprehensively...
This federal Project Grant award of $751,442 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, Los Angeles (UCLA) supports research to optimize and evaluate a brain-penetrant CRISPR-based gene editing therapy for Alzheimer's disease (AD). The goal is to use CRISPR technology to edit the APOE4 gene, a major genetic risk factor for sporadic AD, and convert it to the benign APOE3 variant in the brains of AD model mice and rats. The research...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $745,092 to the University of Virginia to investigate the role of RNA modification in the pathogenesis of Alzheimer's disease and related tauopathies. The 5-year project aims to: Decode the epitranscriptomic profiles impacted by tau pathology using advanced sequencing techniques to improve understanding of Alzheimer's disease mechanisms at the epitranscriptomic level. Determine the...
This federal Project Grant award from the Department of the Army Medical Command, under the Military Medical Research and Development program (CFDA 12.420), provides $509,979.00 to the University of North Carolina at Chapel Hill (UNC-CH) to support research on "Potentiated Chip Variants as Therapeutics to Alleviate Tau Pathology and Neurodegeneration." The funding will enable UNC-CH to conduct advanced biomedical research focused on transforming healthcare for military service...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development of a novel, scalable, allogeneic cell therapy platform utilizing human induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor (CAR) macrophages to address both tau-mediated pathology and associated inflammation in Alzheimer's disease and related dementias. The $734,778 award, effective January 15, 2025 through December 31, 2026, will fund the evaluation of various...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $816,661.00 to The Regents of the University of California, San Francisco (UCSF) to conduct comprehensive research into the molecular and cellular mechanisms by which abnormal tau protein leads to neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project aims to systematically map the impact of tau pathology on the cellular proteome, including through disruptions...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $419,375 to the University of Florida to investigate the role of the protein tau and its interaction with cellular RNA in the development of neurodegenerative disorders, such as Alzheimer's disease. The research aims to identify specific RNA motifs that may either enhance or inhibit the formation of tau-based biomolecular condensates, which are associated with the toxic accumulation of...
The National Institute on Aging (NIA) awarded a $833,173 Project Grant under the Aging Research program (CFDA 93.866) to the University of North Carolina at Chapel Hill (UNC-CH) for the project "Optimization of a Potent and Cell Active CK2 Chemical Probe for Alzheimer's Disease Therapy". The project aims to develop and optimize a potent and selective chemical probe targeting the protein kinase CK2, which has been identified as a potential therapeutic target for Alzheimer's disease. Key...
The University of North Carolina at Chapel Hill (UNC-CH) received a $424,095 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop a CRISPR/Cas13 gene therapy targeting the tau protein for the treatment of Alzheimer's disease and other tauopathies. The project aims to identify and validate optimal guide RNAs to deplete specific tau isoforms in neurons, and evaluate the therapeutic potential of this approach in preclinical Alzheimer's disease mouse models. Key products and services to be delivered include computational guide RNA design, in vitro and in vivo testing in cell lines and primary neurons, and efficacy studies in early and late stage Alzheimer's disease mouse models. This innovative research seeks to advance gene therapy approaches to reduce tau levels as a novel treatment modality for dementia patients. The award period runs from September 1, 2023 to August 31, 2025.