Project Grant R21AG090917
- This federal Project Grant award of $777,869 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports a randomized, double-blind, controlled, multi-center clinical trial to investigate the use of colchicine in treating Calcium Pyrophosphate Deposition Disease (CPPD), a prevalent but underserved form of inflammatory arthritis. The goal is to better understand colchicine's impact on the NLRP3 inflammasome and downstream pathways, which play a key role in CPPD...
- This $109,076 project grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) on November 27, 2025, aims to investigate the impact of modulating synovial mechanobiology to mitigate disease progression in osteoarthritis (OA). The project will evaluate the effect of genetic and pharmacologic suppression of non-muscle myosin II (NM-II) on fibroblast-like synoviocyte (FLS) activation, synovial fibrosis, and OA pathogenesis using in vitro and in vivo models. The research is...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $688,634.00 in funding to The Hospital For Special Surgery Fund, Inc. (dba HSS Foundation) from December 1, 2024 to November 30, 2029. The award supports research to investigate the mechanisms by which the constitutive type-I interferon (IFN-I) response suppresses osteoblastogenesis and bone formation, especially in the context of inflammatory conditions like rheumatoid...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $166,488 Project Grant to the University of California, Davis to investigate the role of hypoxia-inducible factor-2a (HIF-2a) signaling in age-induced bone loss. The project aims to identify mechanisms underlying bone deterioration with aging and develop novel therapies to reverse age-related osteoporotic bone loss and improve fracture resistance. The project period runs from December...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
- The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $506,000 Project Grant to the Scripps Research Institute to engineer a novel biomolecular condensate (BMC)-based tool with tunable physicochemical properties. The goal is to create an orthogonal selective autophagy receptor (SAR)-like BMC capable of supporting autophagosome biogenesis and selective cargo recruitment. This will enable detailed investigation of the biophysical regulatory mechanisms of BMCs in autophagy, which...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $749,030 to The Trustees of Columbia University in the City of New York to conduct research on the mechanisms connecting calcium signaling and autophagy defects in Alzheimer's disease (AD) neurons. The goal is to understand how dysregulation of neuronal calcium (Ca2+) signaling drives impaired autophagy, a key pathological process in AD. The research will evaluate the effects of...
- This $146,070 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how the accumulation of senescent cells and their secretory phenotypes impact osteocyte mechanobiology in a 3D bone-mimicking microenvironment. The goals are to: (1) acquire experimental skills and career training to expand the researcher's program into cellular aging/senescence and molecular biology; (2) investigate how local vs. systemic senescent cells and...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
This $225,000 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support research to understand the biological mechanisms underlying calcium pyrophosphate deposition disease (CPPD), a common yet understudied age-related joint disease affecting over 30 million people worldwide. The research aims to develop advanced animal models to study CPPD disease progression and identify potential molecular pathways and therapeutic interventions. By elucidating the quantifiable, dose-related mechanisms of CPPD development, this high-risk, high-reward project seeks to significantly advance scientific understanding and treatment of this debilitating condition. The grant was awarded to the University of South Florida, a leading research institution in the field of aging research, to conduct this work over a period of nearly 3 years from September 2025 to May 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.0k | 8/26/25 |