Project Grant R21AG089638
Award Date
9/1/24
Completion Date
8/31/26
Dollars Obligated
$401K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Gainesville, FL 32611, USA
Similar Awards
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,234,905.00 in funding to The University of Iowa to support research aimed at understanding the underlying mechanisms responsible for cognitive fluctuations in Lewy body disorders (LBD). The project will use mouse models to evaluate how the accumulation of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,510,600 to the University of Wisconsin - Madison to conduct research on mapping synaptic density in prodromal and manifest Lewy body dementia (LBD). The key objectives are to: (1) map differences in synaptic density between healthy controls, individuals with rapid eye movement sleep behavior disorder, early-stage Parkinsonism, and mild cognitive impairment with Lewy bodies; (2) determine...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and test an advanced magnetic resonance imaging (MRI) technique called velocity-selective arterial spin labeling (VSASL) to serve as a reliable biomarker for detecting early cognitive impairment and disease progression in patients with Lewy body dementia (LBD). The $420,683 award, with a period of performance from September 2024 to July 2029, will fund technical refinements to the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $2,273,637 to The Johns Hopkins University to conduct a comprehensive study of plasma and brain lipidomics (lipid profiling) and their associations with Alzheimer's disease, dementia, and cognitive decline. The study will leverage advanced lipidomics technology to quantify over 1,500 lipid species in plasma samples from 3,868 participants in the Cardiovascular Health Study and postmortem brain...
The National Institutes of Health National Institute on Aging awarded $3,521,744 under the Aging Research federal grant program (CFDA 93.866) to Rutgers, The State University of New Jersey for its project titled "SINGLE-NUCLEI MULTIOMIC ANALYSIS OF DLB PROGRESSION." The project aims to analyze changes in post-mortem brain tissue across stages of dementia with Lewy bodies progression using single-nuclei multi-omic techniques. Specifically, the awardee will conduct neuropathological...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) federal grant program, aims to develop novel lipid nanoparticle (LNP) formulations for efficient delivery of nucleic acid therapeutics to the brain to treat Alzheimer's disease (AD). The $835,417 award will fund research to synthesize BBB-crossing lipids, formulate LNP-RNA constructs, and evaluate their therapeutic effects, pharmacokinetics, and safety in mouse AD models. The comprehensive...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $655,638 to the University of Denver to develop and test synthetic protein mimetics as potential therapeutics for Lewy body dementia (LBD). The key products and services being delivered under this 2.5-year award include: Optimization and testing of the pharmaceutical properties of oligopyridylamide (OP) synthetic protein mimetics to inhibit alpha-synuclein aggregation and Lewy...
This three-year, $4.766 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, aims to clarify the neuropathological, molecular, and genetic differences between Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) through the Aging Research grant program (CFDA 93.866). The J. David Gladstone Institutes will use digital pathology, artificial intelligence, single-nuclei RNA sequencing, and spatial transcriptomics on...
This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...