This Project Grant award of $614,424 from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research to illuminate early microglial dysfunction in Alzheimer's disease (AD). The study aims to integrate novel explainable AI techniques with deep learning methods to better define AD-specific microglial states and pathways from single-cell brain data. As proof-of-concept, the researchers will model the combined effects of AD stimuli and neuronal injury on...
This $205,619 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to map the landscape of the aged human brain and model neurodegenerative diseases like Alzheimer's. The University of Washington will apply explainable AI methods to human brain datasets to identify molecular drivers of brain aging, then manipulate these drivers in human induced pluripotent stem cell (iPSC) models to generate aging phenotypes in neurons and glia. This two-phase...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will develop explainable and ethical artificial intelligence (AI) models to assist in the diagnosis and prognosis of Alzheimer's disease (AD). The $738,014 award, running from August 2024 to April 2029, will leverage multimodal data fusion and cerebrospinal fluid proteomics to enhance understanding of AD pathophysiology. The goal is to create improved and ethical AI-based clinical...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $622,401 to the University of Southern California (USC) to conduct advanced research on Alzheimer's disease and related dementias (ADRD). The project aims to develop novel deep learning and event-based modeling techniques to elucidate the causal sequence of brain biomarker changes that lead to ADRD, as well as identify modifiable lifestyle factors that may influence these brain alterations....
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This $372,690 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to comprehensively understand the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The principal investigators at the University of California, Berkeley will develop novel statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different subpopulations of AD patients. This insight is expected to reveal optimal treatment...
This federal Project Grant award, valued at $972,000.00 and awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to characterize the genetic architecture underlying the onset of amyloid positivity in Alzheimer's disease (AD). The principal investigator will leverage advanced imaging and genetic analysis techniques, including artificial intelligence, to estimate the age of amyloid-beta onset from over 16,000 positron emission tomography scans. This research seeks to...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This $3,845,311 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research at the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using patient-derived induced neurons (iNs). The project aims to better understand the mechanisms that cause mild cognitive impairment (MCI) and the progression to AD, integrating multi-omic analysis of MCI patient-specific iNs with polygenic risk scores....
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...