Project Grant K99AG088478
- Project Grant Summary The University of Texas at Austin received a $541,700 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded June 12, 2026, with completion targeted for May 31, 2031. The project develops advanced quantitative three-dimensional imaging techniques for measuring cerebral blood flow (CBF) during stroke. Specifically, the research...
- Grant Award Summary The University of Rochester received a $346,500 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the 21st Century Cures Act—Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), effective August 1, 2025 through July 31, 2027. This research project aims to develop and validate spatiotemporally optimized transcranial electrical stimulation (TES) techniques to selectively target cognitive...
- Federal Project Grant Award Summary Tufts Medical Center Parent, Inc. received a $616,031 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded May 5, 2026, with completion targeted for February 28, 2031. The grant funds basic neuroscience research investigating the role of arterial endothelial Pannexin 1 (PANX1) channels in ischemic stroke...
- This $428,883 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) aims to examine the effects of individualized transcranial alternating current stimulation (tACS) on phonological short-term memory performance in chronic stroke survivors with aphasia. The key objectives are to identify optimal tACS targets, frequency, and electric field coverage based on...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the Regents of the University of Michigan a $633,146 Project Grant effective August 4, 2025, through July 31, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative addresses the identification of modifiable factors associated with vascular cognitive impairment and dementia (VCID) occurring after stroke, a...
- Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS), operating under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded Washington University a Project Grant of $231,264 on April 8, 2026, with an ultimate completion date of March 31, 2031. The award funds research to identify and validate cerebroprotective drug targets in human subjects by analyzing transcriptomic signatures obtained from blood...
- Federal Project Grant Award Summary Magnetic Tides, Inc. received a $936,787 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective September 1, 2025, through August 31, 2028. The award funds development and validation of Kilohertz Transcranial Magnetic Perturbation (KTMP), a novel non-invasive brain stimulation technology designed to enhance...
- Grant Award Summary Strokebridge Inc. received a $1.33M Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 6, 2025, with completion targeted for June 30, 2030. The research project, "Identifying Cortical and Brainstem Regions Contributing to Partial Hand Function Post-Stroke," will investigate the neurological mechanisms...
- This federal Project Grant award of $498,429, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to identify the key factors that determine an individual's response to transcranial direct current stimulation (tDCS). The research aims to apply machine learning algorithms to a large, multimodal dataset of over 225 tDCS-fMRI sessions to determine which factors, such as baseline task performance, brain...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded $228,641 to the University of Maryland, Baltimore on June 16, 2026, for research extending through May 31, 2031. The funded project develops automated diagnostic and therapeutic tools for managing paroxysmal sympathetic hyperactivity (PSH)—a severe autonomic dysfunction...
NON-INVASIVE BRAIN STIMULATION AND NEUROVASCULAR MECHANISMS OF POST-STROKE COGNITIVE IMPAIRMENT - PROJECT SUMMARY STROKE IS THE LEADING CAUSE OF DEATH AND LONG-TERM DISABILITY IN THE UNITED STATES. UP TO 60% OF STROKE SURVIVORS DEVELOP POST-STROKE COGNITIVE IMPAIRMENT (PSCI) IN THE FIRST YEAR AFTER STROKE. PSCI IS A SIGNIFICANT PUBLIC HEALTH PROBLEM, AS IT CAN LEAD TO A LOSS OF INDEPENDENCE, REDUCED QUALITY OF LIFE, AND INCREASED HEALTHCARE COSTS. DESPITE ITS HIGH PREVALENCE, THERE IS NO ESTABLISHED TREATMENT FOR PSCI. NEW AND INNOVATIVE TREATMENTS ARE NEEDED TO IMPROVE COGNITIVE FUNCTION IN STROKE SURVIVORS WITH PSCI. TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) IS A NON-INVASIVE BRAIN STIMULATION TECHNIQUE THAT HAS SHOWN PROMISE IN IMPROVING COGNITIVE FUNCTION IN A VARIETY OF CONDITIONS, INCLUDING STROKE. TDCS WORKS BY DELIVERING A WEAK ELECTRICAL CURRENT THROUGH THE SCALP. THIS CURRENT CAN MODULATE THE ACTIVITY OF NEURONS IN THE BRAIN. WHILE TDCS HAS BEEN SHOWN TO IMPROVE COGNITIVE FUNCTION IN STROKE SURVIVORS, THE MECHANISM BY WHICH THIS EFFECT IS MEDIATED REMAINS UNDERSTUDIED. ALTHOUGH MOST EXISTING STUDIES HAVE PRIMARILY FOCUSED ON THE NEURONAL EFFECTS OF TDCS, BRAIN STIMULATION HAS A BROAD EFFECT ON A VARIETY OF BRAIN CELLS AND SEVERAL STUDIES REPORT THAT TDCS CAN INCREASE RESTING CEREBRAL BLOOD FLOW BOTH IN ANIMALS AND HEALTHY INDIVIDUALS. HOWEVER, WHETHER TDCS IS CAPABLE OF MODULATING HEMODYNAMIC RESPONSES IN PSCI IS SIGNIFICANTLY UNDERSTUDIED. THIS PROJECT WILL INVESTIGATE THE POTENTIAL OF TDCS AS A THERAPEUTIC INTERVENTION TO IMPROVE NEUROVASCULAR COUPLING (NVC) AND COGNITIVE FUNCTION IN STROKE SURVIVORS WITH PSCI. NVC IS A CRITICAL MECHANISM THAT ALLOWS THE BRAIN TO MATCH BLOOD FLOW TO METABOLIC DEMAND. CURRENT CLINICAL EVIDENCE INDICATES THAT NVC IMPAIRMENT IS ASSOCIATED WITH PSCI. IN AIM 1, I WILL COMPREHENSIVELY EVALUATE NVC RESPONSES IN STROKE SURVIVORS WITH AND WITHOUT COGNITIVE IMPAIRMENT, AND COMPARE THEIR NVC RESPONSES TO HEALTHY SEX AND AGE MATCHED CONTROLS. IN AIM 2, I WILL CONDUCT A PROSPECTIVE SHAM-CONTROLLED CLINICAL TRIAL TO DETERMINE IF ACTIVE TDCS LEADS TO A SIGNIFICANT IMPROVEMENT OF NVC RESPONSES IN STROKE SURVIVORS AND WHETHER THESE CHANGES ARE ASSOCIATED WITH IMPROVEMENTS IN COGNITIVE PERFORMANCE. THIS PROJECT HAS THE POTENTIAL TO DEVELOP A NOVEL AND EFFECTIVE TREATMENT FOR PSCI. BY USING A MULTIMODAL APPROACH (SIMULTANEOUS FNIRS-EEG), THIS PROPOSAL AIMS TO INVESTIGATE A POTENTIALLY REVERSIBLE MECHANISM OF COGNITIVE DECLINE FOLLOWING STROKE AND CONTRIBUTES TO THE ADVANCEMENT OF NEUROSCIENCE RESEARCH IN VASCULAR COGNITIVE IMPAIRMENT.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($33k) | 1/13/26 | ||
| Not listed | $0 | 5/27/25 | ||
| Not listed | $0 | 5/27/25 | ||
| Not listed | $108.1k | 8/1/24 | ||
| Not listed | $108.1k | 8/1/24 |