Project Grant R21AG088163

Award Date 6/1/25
Completion Date 5/31/27
Dollars Obligated $459K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Charlestown, MA 02129, USA
Similar Awards
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $2,173,794.00 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research aimed at developing strategies to enhance adult hippocampal neurogenesis (AHN) and brain-derived neurotrophic factor (BDNF) as a potential therapeutic approach for treating cognitive decline in Alzheimer's disease (AD). The research project seeks to: 1) explore the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The total award amount is $195,896.00 over a period from October 26, 2024 to April 30, 2026. The research will be conducted by Wake Forest University Health Sciences, a leading academic medical center and established...
This $831,583 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to characterize microvascular impairment and associated physiological mechanisms in adults with elevated genetic risk for Alzheimer's disease. The primary awardee, The General Hospital Corporation (doing business as Massachusetts General Hospital), will enroll a cohort of adults aged 40-80 to investigate how APOE-E4 genotype, a key genetic risk factor for Alzheimer's, relates to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), provides $487,574 in funding to elucidate the role of reactive astrocytes in the progression and clearance of phosphorylated tau (pTau) in Alzheimer's disease. The key objectives are to: 1) investigate whether astrocyte upregulation of the cytoskeletal protein GFAP has a protective effect on...
The Washington University in St. Louis, Office of Sponsored Research Services Division, received a $2,133,060 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research to investigate the sex-dependent effects of stress on the accumulation of amyloid-beta (Aβ) and tau proteins, which are hallmarks of Alzheimer's disease pathology. The study aims to elucidate the signaling pathways that mediate the differential...
This Project Grant award of $332,096 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support a pilot study to evaluate the feasibility of non-invasive imaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The study aims to investigate the effect of moderate exercise on slowing AD progression and any potential gender differences. The awardee, The General Hospital...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The General Hospital Corporation (doing business as Massachusetts General Hospital) is for a 2-year research project titled "INFERENCE BY INTERFERENCE: TASK-DEPENDENT PUPIL RESPONSES AS AN EARLY DETECTION METHOD FOR ALZHEIMER'S DISEASE RELATED BRAINSTEM FUNCTIONAL CHANGE". The $426,353 project aims to identify early biomarkers of Alzheimer's disease by studying pupil responses during...
The National Institute on Aging (NIA) awarded a $795,730 Project Grant (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on understanding the neural underpinnings of "grit" and its relationship to cognitive resilience in aging. The research aims to demonstrate a causal link between the functioning of the anterior mid-cingulate cortex (MCC), an individual's level of "grit" or...
This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large...
The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $148,568 Project Grant to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its linkages to Alzheimer's disease pathology. The proposed research will use a multilevel, multimodal framework to study the behavioral and neurobiological mechanisms of age-related shifts in motivation to perform cognitively effortful activities, and directly...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $459,250 to The General Hospital Corporation (dba Massachusetts General Hospital) to investigate the impact of stress and resilience on the progression of Alzheimer's disease pathology and cognitive function. The 2-year project aims to leverage longitudinal data from established research cohorts to determine the temporal associations between stress, resilience, amyloid and tau pathology, and cognitive changes over time. The goal is to enhance understanding of the risk factors and neurobiological mechanisms underlying Alzheimer's disease, with the potential to inform future prevention strategies that promote healthy aging. This research builds upon MGH's extensive expertise in neurodegenerative disease research and its strong track record of federal grant awards from agencies like the National Institutes of Health.

Generated 6/17/25, 3:04 AM