This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $459,250 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the impact of stress and resilience on the development of Alzheimer's disease (AD) pathology and cognitive function over time. The overarching objective is to elucidate the mechanisms by which stress confers increased risk for AD and identify modifiable factors associated with...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brandeis University will conduct research to understand the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The $148,568 award, running from November 2024 to January 2026, will employ a multilevel, multimodal approach using behavioral, psychophysiological, neuroimaging, and naturalistic methods. Key...
This federal Project Grant award, funded by the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research), aims to uncover cognitive resilience factors and identify potential drug combinations that could enhance resilience in Alzheimer's disease (AD) individuals. The University of Texas Health Science Center at Houston was awarded $897,000.00 to develop an interpretable deep learning framework called the Interpretable Generative Transcriptional Program (IGTP) to model cognitive...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
This National Institute on Aging (NIA) Project Grant, CFDA 93.866 Aging Research, was awarded to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to profile and forecast individual progression in Alzheimer's disease and related dementias (ADRD) using machine learning. The $129,330 grant will fund a project to deploy a multi-modal data framework leveraging decades-long in vivo and digital biomarkers to classify ADRD subtypes and predict...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
This $454,225 Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) will support research at The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop new methods for assessing "effective reserve" in patients with acute ischemic stroke. The key objectives are to: 1) investigate the concept of effective reserve and its feasibility in acute ischemic stroke patients using two large...