This federal Project Grant award, R21AG084912, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The University of Iowa. The award, totaling $427,625.00 from September 30, 2023 to September 29, 2025, will support research to investigate the role of the protein ISG15 and ISGylation in cellular senescence and the senescence-associated secretory phenotype (SASP). The research will map the senescence-associated ISGylome using proteomic strategies, compare ISGylation...
This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $243,750 to the Sanford Burnham Prebys Medical Discovery Institute to conduct research on the impact of aging on the initiation and progression of pancreatic ductal adenocarcinoma (PDAC). The key objectives are to 1) examine how the aging stroma (tumor microenvironment) affects PDAC tumor growth and metastasis, and 2) investigate the influence of age on the intrinsic oncogenic potential of the...
This Project Grant award from the National Institute on Aging (NIA, CFDA 93.866 Aging Research) provides $147,486 to Albert Einstein College of Medicine to study the role of chaperone-mediated autophagy (CMA) in cellular senescence and aging. The research aims to understand: 1) how CMA activity changes upon induction of senescence, 2) if CMA modulates the kinetics of senescence and by what mechanisms, 3) if CMA is required for clearance of senescent cells by the immune system, and 4) if...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $133,353 to Mayo Clinic to investigate the molecular mechanisms of T cell-mediated surveillance of senescent cells under both physiological and aging conditions. The research aims to define how senescent cells deploy their secretome to sensitize human T cells, assess co-stimulatory and co-inhibitory interactions between senescent cells and T cells, and perform translational studies...
This Project Grant award of $794,978.00 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support a longitudinal study to examine accelerated epigenetic aging as a mechanism linking socioeconomic disadvantage across the lifespan to cognitive decline in midlife. The research will leverage the Adult Health and Behavior Project's existing data on individual socioeconomic status, neuropsychological assessments, and stored blood samples to analyze...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $789,664.00 to the Icahn School of Medicine at Mount Sinai to conduct research on understanding the cellular and spatial tissue changes in the human lung and peripheral blood associated with aging. The research will use single-cell RNA sequencing and spatial transcriptomics profiling, combined with advanced computational analyses, to characterize the effect of age on the cellular...