Project Grant R21AG085888

Award Date 7/15/24
Completion Date 6/30/26
Dollars Obligated $239K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $430,603 provides funding to the University of Toledo Health Science Campus Division to conduct research on the mechanisms by which age-associated transfer RNA (tRNA) modification aberrations affect tRNA cleavage and senescence. The key objectives are to: 1) Examine tRNA and tRNA-derived fragment (tsRNA) modification levels in aged tissues commonly affected by age-induced dysfunction,...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brandeis University for $660,908 supports research to uncover the functions of circular RNAs (circRNAs) in the aging process. The project aims to: 1) determine the mechanisms behind circRNAs that promote aging, 2) investigate the extent and requirements for circRNA translation and its relationship to aging, and 3) define the relationship between the FOXO regulon and circRNAs in aging. The award period...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
The federal Project Grant award R01AG086692 was provided by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866) to Brandeis University. The $331,187 award will fund a 4-year study to understand the role of retrotransposon activity in aging and age-related phenotypes using the Drosophila model system. The goals of the project are to characterize a Drosophila system to determine whether transposon activity is a cause or effect of the aging process. This...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $146,922 to Rockefeller University to conduct research aimed at understanding the molecular determinants of the mRNA export platform and how aging-associated mutations affect its assembly and impact gene regulation. The key objectives are to: 1) Generate a high-resolution integrative model of the mRNA export platform using techniques like cryo-EM and crosslinking mass spectrometry, and...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $351,750 to Yale University to investigate the role of the protein NLRX1 in age-related changes to the immune system, particularly T cell function. The 5-year project aims to elucidate how decreases in NLRX1 may contribute to the expansion of memory T cells, decreased naive T cell survival, and other age-associated T cell alterations. The research will explore the mechanisms by which NLRX1...
This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $651,793 to the University of California, San Diego (UCSD) to conduct research on translation fidelity in hematopoietic stem cell aging and longevity. The goal is to determine if young adult hematopoietic stem cells have elevated translation fidelity compared to older stem cells, and if enhancing translation fidelity can improve stem cell fitness and extend healthspan and lifespan. The...

This Project Grant award, funded by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, is providing $239,338 to the University of Alabama at Birmingham (UAB) to investigate the role of tRNA-derived short and long RNAs in the aging process. The project aims to determine if these RNA species contribute to lifespan or proteostasis changes associated with aging, through studies in the yeast model organism. Key aspects include overexpressing or depleting the tRNA-derived short RNAs (tRNA halves) to assess their effects, as well as characterizing the extended tRNA transcripts that accumulate with age. This exploratory research, running from July 2024 to June 2026, brings together experts in yeast aging and tRNA biology to elucidate potentially novel mechanisms underlying the aging phenotype. A subaward of $542,804 has also been provided to the University of Virginia to support this collaborative project.

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