This federal Project Grant award of $614,424 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington aims to investigate the role of microglia, the brain's immune cells, in the early progression of Alzheimer's disease (AD). The key products and services to be delivered under this 2-year award include: Applying novel explainable AI techniques and deep learning methods to single-cell brain data to better define subtle microglial changes and AD-specific...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
This $10,847,672 Project Grant awarded by the National Institute on Aging (part of the National Institutes of Health) under the Aging Research federal grant program (CFDA 93.866) aims to elucidate the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The research will leverage human postmortem brain samples, single-cell genomic profiling, and animal models to investigate how microglia regulate the balance between vascular CAA and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,357 in funding to the Research Foundation of the City University of New York (RFCUNY) for research to elucidate molecular mechanisms underlying the neurodegenerative reprogramming of microglia in Alzheimer's disease. The key objectives are to determine how the integrated stress response pathway triggers chromatin remodeling in microglia, examine how this exacerbates their stressed...
This $427,625 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The grant was awarded to The Washington University in St. Louis to support research evaluating novel transcription factors that regulate astrocyte identity, reactivity, and their roles in the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD). The research aims to systematically evaluate 10 candidate transcription factors identified...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The $794,341 award, effective from January 1, 2025 through December 31, 2029, will be conducted by the University of Illinois in Chicago. The research aims to leverage experimental mouse models, molecular characterization of...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
This $427,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the mechanisms by which microgliopathy, a genetic neurological disorder, causes early-onset dementia. The research will investigate how the loss of the DAP12 protein in microglia, the immune cells of the brain, leads to heightened signaling of the RUNX and STAT3 pathways. This dysregulation is hypothesized to disrupt normal microglial functions and induce brain pathology and dementia. The 2-year project, awarded to the Washington University in St. Louis, will utilize human induced pluripotent stem cell-derived microglia and mouse models to explore these mechanisms and their impact on microglial gene expression and functionality. The findings may provide insights into the pathogenic pathways and therapeutic targets for common dementias.