This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $637,526 to Duke University to conduct research on the role of sickle red blood cells (RBCs) in activating neutrophils and promoting vaso-occlusion in sickle cell disease (SCD). The key objectives of the research are to: 1) delineate the characteristics of sickle RBCs that contribute to neutrophil activation, 2) examine the...
This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to evaluate methods for improving the homing and engraftment efficiency of CD34+ cells from sickle cell disease (SCD) patients. The $128,100 award to the New York Blood Center, Inc. will support research to determine if co-infusing the CD34+ cells with their flow-through accessory cells, normally discarded after CD34+ cell...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on identifying and characterizing clonal expansions that increase with age across various tissues, and understanding how these clonal mosaicism patterns are influenced by aging and age-related diseases. The $159,492 award to Weill Medical College of Cornell University aims to (1) develop tools to accurately identify somatic variants from publicly available...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $608,126 to the Regents of the University of Minnesota to develop and validate single-cell biomarkers for predicting clinical outcomes in sickle cell disease (SCD). The research aims to: 1) define the relationship between SCD adverse outcomes and single-cell biochemical/mechanical properties to identify the most promising biomarkers; 2) define the...
This Project Grant award of $444,125 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Duke University to investigate the impact of red cell exchange (RCE) procedures on neutrophil function in sickle cell disease (SCD) patients. The research aims to determine if RCE, which replaces abnormal sickle hemoglobin red blood cells with normal hemoglobin cells, can modulate neutrophil reactivity and function,...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $465,000 in funding to Bloodworks, a non-profit organization based in Seattle, WA. The award supports research into the mechanisms by which chronic inflammation disrupts hemostatic function in sickle cell disease (SCD). Specifically, the project aims to investigate how TNF-driven inflammation in SCD blocks autophagy and mitophagy in...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
The National Institute on Aging (CFDA 93.866) awarded a $1,274,993 Project Grant to Epicypher, Inc. to develop a new approach called Reverse Transcribe & Tagmentation (RT & TAG) for identifying chromatin-associated RNAs (CARNAs), including nascent RNA transcripts, to accelerate aging and Alzheimer's disease/age-related dementia (AD/ADRD) research. The central innovation is an immunotethering-based method for in situ targeted tagmentation of CARNAs. The project also involves developing...
This Project Grant award of $2,653,601 from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) supports research to identify genetic, environmental, and molecular factors that influence the rate of clonal hematopoiesis (CH) expansion and associated health outcomes across the human lifespan. The key objectives are to: 1) apply a computational method to estimate CH expansion rates in over 1.6 million individuals to identify genetic factors conferring...