This $101,925 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate the role of the propionate metabolism pathway in the aging process. The 2-year project aims to: Continue studying the impact of methylmalonic acid (MMA), a metabolite in the propionate pathway, on cell senescence and aging-associated pulmonary fibrosis. Characterize a novel function of propionyl-CoA (P-CoA), another pathway...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $158,918 to Vanderbilt University to conduct a multi-omic study exploring the impact of lifestyle variation on immunological aging patterns. The study will focus on characterizing age-associated molecular phenotypes such as gene expression, DNA methylation, and clonal hematopoiesis in peripheral blood samples collected from subsistence-level populations (Tsimane, Turkana, Orang Asli) and a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive investigation into the relationship between mitochondrial function and aging-related diseases. The $2,672,656 award to The Johns Hopkins University will leverage genetic variation data, metabolomics, and proteomics to identify novel biomarkers of mitochondrial function and assess their causal associations with all-cause mortality, cardiovascular disease, and frailty. The...
This $432,418 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Vanderbilt University to discover and characterize small molecule modulators of the NURR1-RXR protein complex. The goal is to develop chemical tools that can be used to study the role of NURR1-RXR in regulating neuronal function and neuroinflammation, which are implicated in neurodegenerative diseases like Alzheimer's and Parkinson's. The 2-year project will...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $376,250 to Vanderbilt University Medical Center (VUMC) to characterize the metabolism and quantification of specialized pro-resolving lipid mediators (SPMs). The goal is to gain a comprehensive understanding of SPM transformation, including identifying metabolic pathways and the effect of common medications like...
This Project Grant award of $1,188,750.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) Federal Grant Program supports advanced research on lipoxygenases, their associated enzymes and proteins, and the mechanisms of biosynthesis and fate of lipid oxidation products. The research program at Vanderbilt University focuses on two key areas: 1) uncovering the mechanistic basis of how a 12R-lipoxygenase (12R-LOX)...
This $222,852 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to computationally assess the impact of aging-related oxidative stress on the human proteome using a novel deep learning methodology. The project will construct a deep learning-based atomic protein structure embedding method to predict the likelihood of oxidation-related modifications occurring across the entire human proteome. The...
This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...
This $478,765 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center supports a comprehensive investigation into the metabolism of F-isoprostanoids, which are emerging biomarkers of oxidative stress.
The key objectives are to: 1) use human liver microsomes to identify metabolites of F-isoprostanoid isomers generated from polyunsaturated fatty acid oxidation, and 2) establish and validate a robust LC/MS method to quantify these F-isoprostanoid metabolites in human urine samples. The research aims to redefine the understanding of F2-isoprostane metabolism and establish a strategy to comprehensively assess this important lipid peroxidation biomarker. This work will inform future applications examining the role of isoprostanoids in human physiology and disease pathogenesis related to aging and oxidative stress.