This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $107,272 to Brandeis University to investigate the relationship between dopamine function, reinstatement of fMRI activation patterns, and reward memory in cognitively normal older adults. The project aims to quantify endogenous dopamine release and use multi-voxel pattern analysis to measure the persistence of reward-related fMRI activation during rest periods, and how these neural measures relate...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $157,568.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to study the joint effects of dopamine and tau on cognition in aging. The project will leverage multimodal MRI/PET neuroimaging to examine how increased dopamine levels and tau pathology interact to impact reward memory and hippocampal neural activity in older adult participants. Specific...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The research will use behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand age-related shifts in motivation and neuromodulation that impact older...
This federal Project Grant award, with identification number R21AG085288, was provided by the National Institute on Aging under the Aging Research grant program (CFDA 93.866). The $434,500 award, with a period of performance from September 1, 2024 to June 30, 2026, will support research into the dopaminergic mechanism underlying familiarity bias and memory interference in aging. The key objectives of this project are to investigate how dysfunction in dopamine neurons projecting to the lateral...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $528,876 to Emory University to conduct research investigating the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The 5-year project, beginning June 1, 2025, aims to develop new analytical tools that can integrate transcriptome-wide and proteome-wide association studies with genome-wide association data...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brandeis University provides $106,464.00 to conduct research examining the associations among monoamines, tau pathology, and emotional memory in aging. The project aims to use positron emission tomography (PET) methods to assess monoamine synthesis capacity and tau pathology in the brain, and relate these measures to performance on an emotional memory task. The research seeks to provide insights...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $799,700 in funding to the University College London (UCL) to conduct a systems genetics analysis of resilience to tauopathy in Alzheimer's disease and related dementias (ADRD). The key products and services to be delivered under this 5-year grant include establishing a genetically diverse mouse model population (FTD-BXD) to study genetic and molecular factors underlying resilience to...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the cellular...