Project Grant R21AA032119
- The National Institute on Alcohol Abuse and Alcoholism awarded Louisiana State University Health Sciences Center New Orleans $158,600 on November 3, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research identifying the mechanisms underlying alcohol-induced hyperalgesia in adult rats. The project period runs through August 31, 2028, with work performed in New Orleans, Louisiana. The award funds experimental research examining how chronic adolescent alcohol exposure...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Colorado, doing business as University of Colorado-Denver, $1,162,583 on September 10, 2025, under the Alcohol Research Programs (CFDA 93.273) to conduct research combining laboratory-based pain induction and ecological momentary assessment (EMA) methods to examine age-related differences in the relationship between alcohol use, pain, and inflammation. The research tests two hypotheses: that pain...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $578,234 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to establish a translational human laboratory model investigating alcohol's effects on pain in persons with co-occurring alcohol use disorder and chronic pain. The research uses a computer-controlled intravenous alcohol clamp to quantify alcohol's biphasic effects on pain perception—analgesia during the ascending phase and hyperalgesia...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $143,784 Project Grant (CFDA 93.273 - Alcohol Research Programs) to Louisiana State University Health Sciences Center New Orleans on July 30, 2024. The grant will support research to investigate the effects of adolescent opioid exposure on alcohol-induced hyperalgesia (increased pain sensitivity) in adult mice. The research aims to test the hypothesis that exposure to opioids during adolescence increases the magnitude of...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Minnesota $616,849 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate sex differences in cholinergic signaling during alcohol withdrawal. The research examines how acetylcholine signaling in the mesopontine tegmentum and its connections to the ventral tegmental area contribute to alcohol withdrawal symptoms, with particular focus on distinct mechanisms between male and...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Regents of the University of Minnesota $157,040 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) project grant F32AA032727. The funded research investigates neural mechanisms driving compulsive alcohol drinking despite negative consequences, termed aversion-resistant alcohol drinking (ARD). Using optogenetics and simultaneous in-vivo electrophysiology in male and female Long-Evans rats, the project examines how...
- The National Institute on Alcohol Abuse and Alcoholism awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $1,156,082 under the Alcohol Research Programs (CFDA 93.273) on September 25, 2025, to investigate the gut-brain axis and the role of butyrate in neuroinflammation and pain sensitivity. The research examines the relationship between alcohol use disorder, chronic pain, gut dysbiosis, and neuroinflammation, with focus on how gut microbial-derived short-chain...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Research Foundation for the State University of New York $2.12 million on August 4, 2026, under the Alcohol Research Programs (CFDA 93.273) to support research into neurobiological factors contributing to tolerance to the adverse consequences of alcohol. The research examines how individuals vary in their sensitivity to the aversive effects of alcohol and how tolerance to these effects develops following repeated alcohol...
- The National Institute on Alcohol Abuse and Alcoholism awarded Boston Children's Hospital $489,479 under Project Grant R21AA033213 on August 1, 2026, to characterize physical and emotional pain during protracted withdrawal from alcohol use disorder and identify predictive factors and brain-behavior mechanisms underlying these pain syndromes. The research addresses a gap in understanding how physical pain (musculoskeletal, phantom pain) and emotional pain (hyperkatifeia, stress, anhedonia, social...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
The National Institute on Alcohol Abuse and Alcoholism, under the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Minnesota $400,585 on July 16, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the spinal mechanisms of alcohol-induced tactile hypersensitivity. The research addresses the relationship between chronic alcohol consumption and heightened pain sensitivity in individuals with alcohol use disorder. The recipient will conduct exploratory work examining how repeated cycles of chronic alcohol consumption and withdrawal produce maladaptive changes in spinal inhibitory signaling that contribute to hypersensitivity. Preliminary findings indicate that alcohol-induced hypersensitivity is attenuated by antagonism of GABA type A receptors, suggesting disruption of inhibitory neural processing as a mechanism. The project will characterize the role of the chloride transporter KCC2 as a potential intervention target for pain management in the context of alcohol use disorder. Work is performed in Minnesota. The award is structured as an exploratory development grant with a period of performance from July 16, 2026, through June 30, 2028. This assistance type is not renewable, though the recipient may apply for a research project grant on the same topic.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.6k | 7/27/26 |