Project Grant R21AA031964
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $713,580 on August 6, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct imaging research on sex differences in the cortical reward system of people with alcohol use disorder. The research examines dopamine neurotransmission in the mesocortical pathway—which regulates executive functions, reward sensitivity, stress response, and cognitive function—comparing men and women with alcohol use disorder....
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $100,228 under the Alcohol Research Programs (CFDA 93.273) on October 27, 2026, to investigate the neurobiological mechanisms underlying the co-occurrence of alcohol use disorder and post-traumatic stress disorder. The project examines how stress exposure disrupts excitation-inhibition balance in the medial prefrontal cortex, driving increased alcohol consumption and heightened motivation for alcohol use. Using single...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Tufts College $686,774 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct behavioral neurobiology research on stress, alcohol responsivity, and alcohol drinking patterns. The research uses rodent models to investigate how stress exposure alters sensitivity to alcohol's aversive effects and the neural circuits involved. The study employs classical and operant conditioning paradigms combined with...
- The National Institute on Alcohol Abuse and Alcoholism awarded Drexel University $450,372 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate ethanol-induced dysregulation of the astrocyte glucocorticoid system and its role in comorbid alcohol use disorder and depression, particularly in women. The research examines how chronic ethanol exposure perturbs the astrocyte glucocorticoid receptor system, which contributes to stress responsivity, aversion-related...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $167,500 in Project Grant funding to the University of Massachusetts Medical School on September 17, 2025, through the Alcohol Research Programs (CFDA 93.273) for a research study investigating sex differences in excessive alcohol use patterns across young adulthood and middle age. The research will utilize longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine how...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $752,580 on June 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a five-year experimental medicine trial examining semaglutide dose effects on metabolic dysfunction, stress hormones, craving, and alcohol use outcomes in individuals with comorbid alcohol use disorder and obesity. The trial compares semaglutide at 1 milligram and 2 milligram doses against placebo over a 20-week treatment period and...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), a division of the Department of Health and Human Services National Institutes of Health, awarded Yale University $663,419 on August 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate liver sinusoidal endothelial cell (LSEC) inflammation in alcohol-associated liver disease. The research addresses mechanisms by which alcohol disrupts LSEC homeostasis through two converging pathways: IL6 trans-signaling mediated...
- The National Institute on Alcohol Abuse and Alcoholism awarded Weill Medical College of Cornell University $591,468 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct longitudinal neuroimaging analysis identifying neural risk factors for drinking onset in young adulthood. The recipient will apply machine learning analysis to nine years of longitudinal neuroimaging, behavioral, and neuropsychological data from 466 adolescents (baseline ages 12–18 years) enrolled in...
- The National Institute on Alcohol Abuse and Alcoholism awarded $249,000 to the University of Tennessee Health Science Center on March 10, 2026, under the Alcohol Research Programs (CFDA 93.273) for research on the role of somatostatin in the extended amygdala in post-traumatic stress and alcohol use disorder comorbidity. The research applies multidisciplinary neurobiological methods—including in situ hybridization, ex vivo electrophysiology, chemogenetics, viral gene transfer of somatostatin,...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Boston University $580,556 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of pituitary adenylate cyclase activating polypeptide (PACAP) in heavy alcohol drinking and associated anxiety-like behavior. The recipient will conduct mechanistic research using animal models of heavy alcohol drinking combined with pharmacological, molecular, and viral approaches to test whether the...
The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $880,688 on August 4, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research imaging glucocorticoid function in women with childhood trauma and alcohol use disorder. The research uses positron emission tomography with a novel radiotracer called [18F]FMOZAT to investigate brain cortisol as a potential biomarker of stress dysregulation in women with childhood trauma and alcohol use disorder. The project addresses a gap in existing literature by examining glucocorticoid levels in the living human brain, focusing on the enzyme 11B-hydroxysteroid dehydrogenase type 1 (11B-HSD1), which is expressed in brain regions critical to alcohol addiction, including the amygdala and prefrontal cortex. The research responds to increased rates of alcohol use disorder in women over the past decade and evidence that stress may be a more potent factor for alcohol use in women than in men, particularly among those with early life trauma. Performance occurs in Connecticut. The period of performance runs from the award date through July 31, 2028. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3k | 8/27/26 | ||
| Not listed | $439.7k | 8/6/26 |