This $856,625 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports an exploratory randomized controlled trial (RCT) of the effects of oral semaglutide on alcohol craving and consumption. The University of Colorado-Denver, as the prime awardee, will conduct this 2-year study to assess the safety, tolerability, and efficacy of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, compared to placebo for treating alcohol use disorder. The primary objectives are to evaluate the impact of semaglutide on alcohol cue-elicited craving and alcohol consumption. This exploratory trial could inform the design of a larger future RCT to further develop semaglutide as a novel pharmacological treatment for alcohol use disorder.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.4k | 8/28/23 | ||
| Not listed | $427.6k | 8/17/23 | ||
| Not listed | $427.6k | 8/17/23 |