The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $424,194 Project Grant under the Alcohol Research Programs (CFDA 93.273) to George Washington University (The) to conduct research on the genetic architecture underlying the comorbidity of alcohol use disorder (AUD) and chronic pain (CP). The project aims to: 1) Estimate the shared genetic variance contributing to AUD and CP phenotypes and the unique genetic variance for each, 2) Determine the extent to which AUD-CP comorbidity is explained by shared genetics versus a causal relationship, and 3) Explore contextual moderators impacting genetic contributions to AUD-CP comorbidity. The university will employ advanced statistical genetics methods, including genome-wide structural equation modeling, pairwise genome-wide association studies, Mendelian randomization, and genome-wide complex trait analysis, to address these research objectives. The University of Missouri System is a sub-awardee on the project, contributing its expertise in this area of study. This research seeks to advance the understanding of genetic and environmental factors underlying the co-occurrence of AUD and chronic pain, with the goal of informing future efforts to develop more effective prevention and treatment strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $424.2k | 8/2/23 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
23S23S | University Of Missouri System | Project Grant R21AA030360 | $123.8k | 10/16/23 |