Project Grant R16GM165506
- The National Institute of General Medical Sciences awarded The University of Chicago $125,820 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to integrate evolutionary history and biophysics toward combating antibiotic resistance through study of bacterial Na+/H+ antiporters and related proton-coupled transporters. The research targets Na+/H+ antiporters, a diverse family of membrane proteins essential to bacterial stress resistance and virulence...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $186,711 on April 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the regulation of putrescine biosynthesis and its role in PhoQ signal transduction and magnesium homeostasis in Salmonella typhimurium. The project examines how polyamines and magnesium concentrations are coordinately controlled in bacterial cells and how polyamines substitute for magnesium...
- The National Institute of General Medical Sciences awarded Health Research, Inc. Wadsworth Center $386,003 on August 1, 2026, to fund research on mechanisms of bacterial defense against conjugative plasmids and their phages under the Biomedical Research and Research Training program (CFDA 93.859). The research addresses antibiotic resistance by investigating how bacteria defend against conjugative plasmids—which spread resistance genes across bacterial populations—and plasmid-dependent phages...
- The National Institute of General Medical Sciences awarded the University of Illinois $420,618 on August 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on structural and functional vulnerabilities of the bacterial chromosome. The research addresses three phenomena in Escherichia coli: catastrophic chromosome fragmentation induced by potentiated oxidative damage, R-lesions (toxic RNA contaminations of DNA structure), and thymineless...
- The National Institute of Allergy and Infectious Diseases awarded the University of Illinois $440,908 on February 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to identify inhibitors of bacterial peptidyl-tRNA hydrolase (PTH). The recipient will synthesize and optimize derivatives of PTH inhibitor compounds with sub-micromolar IC50 values to enhance their activity against Klebsiella pneumoniae PTH and improve cellular uptake. The work includes expanding...
- The National Institute of General Medical Sciences awarded the University of Illinois $372,016 on July 7, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to deconstruct RNA polymerase III regulation and function through systematic profiling of POL III activity and discovery of new regulatory mechanisms. The research applies genomic and biochemical strategies to characterize POL III transcription breadth and tissue-specific patterns, focusing initially on the...
- The National Institute of General Medical Sciences awarded the University of Massachusetts $2.35 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate non-specific electrostatic interactions of biological macromolecules in physiological and pathological processes. The project examines how highly charged polycationic and polyanionic biomacromolecules — including heparin, neutrophil extracellular traps, and other polymeric species —...
- The National Institute of General Medical Sciences awarded the University of Chicago $451,000 in project grant funding on April 1, 2026, to define the regulatory control of desiccation tolerance in Acinetobacter baumannii, an opportunistic bacterial pathogen that persists on contaminated surfaces through extreme water-loss tolerance. The research investigates the regulatory mechanisms and signal transduction pathways that enable A. baumannii to sense and respond to desiccation stress, focusing...
- The National Institute of General Medical Sciences awarded Midwest Bioprocessing Center, Inc. $313,770 on September 1, 2026, under the SBIR program to develop a scalable fermentation system for producing pseudaminic acids and their CMP-activated derivatives. The award supports Phase I research to establish proof-of-concept for cost-effective biosynthetic production of pseudaminic acid compounds—specifically PSE5AC7AC and analogs PSE5AC7HB and PSE5AC7FM in free and CMP-activated forms....
- The National Institute of General Medical Sciences awarded the University of Illinois Chicago $440,908 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year investigation into the cellular and molecular mechanisms linking dysbiosis, organ injury, and systemic inflammation in multiple organ dysfunction syndrome during critical illness. The research validates dysbiosis as a critical risk factor exacerbating organ injury and systemic...
The National Institute of General Medical Sciences awarded the Board of Trustees of Illinois State University $148,000 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how polyphosphate protects gram-negative bacteria from membrane stress and to examine the impact of pharmacological PPK1 inhibition on biofilm-associated bacteria. The project, titled "Bacterial Responses to Stress—Polyphosphate," will run through May 31, 2030, with work performed in Normal, Illinois. The research addresses the role of polyphosphate, a ubiquitous biomolecule in gram-negative bacteria that contributes to stress resistance, antibiotic tolerance, biofilm formation, and host colonization. The recipient will investigate three major aims: how polyphosphate production protects against polymyxin-induced membrane stress and whether polyphosphate reduces oxidative damage, supports membrane integrity, and promotes stress-responsive gene expression; the impact of mesalamine-mediated inhibition of polyphosphate kinase 1 (PPK1) on biofilm-associated bacteria; and the mechanism by which Staphylococcus aureus stimulates polyphosphate synthesis in other bacteria. Preliminary data suggest that mesalamine, an FDA-approved drug, acts as a potent PPK1 inhibitor and may sensitize bacteria to antimicrobials, offering a bacteria-specific therapeutic strategy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $148.0k | 8/3/26 |