Project Grant R43GM165183
- The National Institute of General Medical Sciences awarded Midwest Bioprocessing Center, Inc. $313,957 on August 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop bioorthogonal nucleotide sugars for glycan research applications using chemoenzymatic production methods. The Phase I award funds demonstration of production of three nucleotide sugars containing bioorthogonal handles through enzymatic pathways. The work encompasses synthesis of initial...
- The National Institute of General Medical Sciences awarded Physical Sciences Inc. $311,847 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a fluorescence-based rapid phage detection system for industrial bioreactors. Physical Sciences Inc. and the University of Connecticut are developing a lyobead assay platform that detects bacteriophage contamination in bioreactor systems within hours. The system uses a sampling chamber loaded with...
- The National Institute of General Medical Sciences awarded the Board of Trustees of Illinois State University $148,000 on August 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how polyphosphate protects gram-negative bacteria from membrane stress and to examine the impact of pharmacological PPK1 inhibition on biofilm-associated bacteria. The project, titled "Bacterial Responses to Stress—Polyphosphate," will run through May 31, 2030,...
- The National Institute of General Medical Sciences awarded Proteovista LLC $306,151 on June 2, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop ClusterBuild, a platform for cost-effective synthesis of large biosynthetic gene clusters up to 100 kilobases in size. ClusterBuild combines DNA microarrays with peptide nucleic acid (PNA)-based error correction and isothermal assembly to enable high-fidelity synthesis of biosynthetic gene clusters derived from...
- The National Institute of General Medical Sciences awarded Scarab Genomics LLC $1.854 million on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a continuous microbial fermentation system using reduced genome E. coli that undergoes programmed autolysis for the manufacture of biopharmaceuticals. Scarab Genomics will optimize a temperature-sensitive lysis system for high-density (>200 OD600) continuous fermentation, integrating...
- The National Institute of General Medical Sciences awarded Brandeis University $398,904 on July 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to synthesize thioaminoketal antimicrobial peptides and determine their mechanism of action. The funded work prepares four classes of cyclic, bioactive peptides with varying structural complexity and antimicrobial potency. A key innovation involves selective thiolation of dehydroamino acids to directly convert linear...
- The National Institute of General Medical Sciences awarded The Ohio State University $410,893 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct genomics-accelerated discovery and biosynthesis research on phosphonic acid natural products. The project, identified as R35GM161629, runs through December 31, 2030, with performance at Columbus, Ohio. The research program aims to discover microbial natural products of chemotherapeutic value, establish...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover novel antimicrobial molecules from clostridial biosynthesis. The project characterizes cobalamin-dependent radical S-adenosylmethionine enzymes fused with non-ribosomal peptide synthetase adenylation domains found in clostridial genomes. The recipient will conduct biochemical characterization of these...
- The National Institute of General Medical Sciences awarded Western Michigan University $532,909 on February 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R15GM163283) to investigate bacterial acid resistance and amino acid metabolism in gastrointestinal pathogens. The research examines how the bacterial second messenger c-di-GMP regulates both amino acid metabolism and acid resistance in E. coli and Shigella, with particular focus on...
- The National Institute of General Medical Sciences awarded Northwestern University $226,884 on March 17, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore the impact of membrane environments on particulate methane monooxygenase (PMMO), a copper-dependent enzyme that catalyzes methane oxidation to methanol. The research determines why native membranes are essential for optimal PMMO activity using a proteoliposome system. Aim 1 reconstitutes PMMO into...
The National Institute of General Medical Sciences awarded Midwest Bioprocessing Center, Inc. $313,770 on September 1, 2026, under the SBIR program to develop a scalable fermentation system for producing pseudaminic acids and their CMP-activated derivatives. The award supports Phase I research to establish proof-of-concept for cost-effective biosynthetic production of pseudaminic acid compounds—specifically PSE5AC7AC and analogs PSE5AC7HB and PSE5AC7FM in free and CMP-activated forms. Pseudaminic acids are non-mammalian sugars found in surface glycoconjugates of major pathogens including Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Acinetobacter baumannii. They function as critical virulence factors and are targets for antimicrobial drug discovery, glycoconjugate vaccine development, and pathogen detection. Current commercial availability is severely limited; PSE5AC7AC and CMP-PSE5AC7AC cost more than $4,000 to $6,000 per milligram, and other derivatives are not commercially available. The project will engineer Escherichia coli fermentation strains expressing five biosynthetic genes from Aeromonas caviae to produce and secrete CMP-activated pseudaminic acids directly into culture media. Phase I milestones include cloning and expressing the biosynthetic genes, co-expressing them in a single E. coli strain to achieve gram-scale production of CMP-PSE5AC7AC, developing purification protocols, and isolating both CMP-PSE5AC7AC and PSE5AC7AC to demonstrate proof-of-concept for research-grade production scales. Work is performed in Peoria, Illinois. The period of performance runs from September 1, 2026, through February 28, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $313.8k | 8/24/26 |